Atypical chemokine receptor 4 (C-C chemokine receptor type 11) (C-C CKR-11) (CC-CKR-11) (CCR-11) (CC chemokine receptor-like 1) (CCRL1) (CCX CKR)
1_MALEQ 6_ NQSTD 11_ YYYEE 16_ NEMNG 21_ TYDYS 26_ QYELI 31_ CIKED 36_ VREFA 41_ KVFLP 46_ VFLTI 51_ VFVIG 56_ LAGNS 61_ MVVAI 66_ YAYYK 71_ KQRTK 76_ TDVYI 81_ LNLAV 86_ ADLLL 91_ LFTLP 96_ FWAVN 101_ AVHGW 106_ VLGKI 111_ MCKIT 116_ SALYT 121_ LNFVS 126_ GMQFL 131_ ACISI 136_ DRYVA 141_ VTKVP 146_ SQSGV 151_ GKPCW 156_ IICFC 161_ VWMAA 166_ ILLSI 171_ PQLVF 176_ YTVND 181_ NARCI 186_ PIFPR 191_ YLGTS 196_ MKALI 201_ QMLEI 206_ CIGFV 211_ VPFLI 216_ MGVCY 221_ FITAR 226_ TLMKM 231_ PNIKI 236_ SRPLK 241_ VLLTV 246_ VIVFI 251_ VTQLP 256_ YNIVK 261_ FCRAI 266_ DIIYS 271_ LITSC 276_ NMSKR 281_ MDIAI 286_ QVTES 291_ IALFH 296_ SCLNP 301_ ILYVF 306_ MGASF 311_ KNYVM 316_ KVAKK 321_ YGSWR 326_ RQRQS 331_ VEEFP 336_ FDSEG 341_PTEPT
1: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus