E3 ubiquitin-protein ligase CCNB1IP1 (EC 2.3.2.27) (Cyclin-B1-interacting protein 1) (Human enhancer of invasion 10) (RING-type E3 ubiquitin transferase CCNB1IP1)
1_MSLCE 6_ DMLLC 11_ NYRKC 16_ RIKLS 21_ GYAWV 26_ TACSH 31_ IFCDQ 36_ HGSGE 41_ FSRSP 46_ AICPA 51_ CNSTL 56_ SGKLD 61_ IVRTE 66_ LSPSE 71_ EYKAM 76_ VLAGL 81_ RPEIV 86_ LDISS 91_ RALAF 96_ WTYQV 101_ HQERL 106_ YQEYN 111_ FSKAE 116_ GHLKQ 121_ MEKIY 126_ TQQIQ 131_ SKDVE 136_ LTSMK 141_ GEVTS 146_ MKKVL 151_ EEYKK 156_ KFSDI 161_ SEKLM 166_ ERNRQ 171_ YQKLQ 176_ GLYDS 181_ LRLRN 186_ ITIAN 191_ HEGTL 196_ EPSMI 201_ AQSGV 206_ LGFPL 211_ GNNSK 216_ FPLDN 221_ TPVRN 226_ RGDGD 231_ GDFQF 236_ RPFFA 241_ GSPTA 246_ PEPSN 251_ SFFSF 256_ VSPSR 261_ ELEQQ 266_ QVSSR 271_AFKVK
1: Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis