Lactosylceramide 4-alpha-galactosyltransferase (EC 2.4.1.228) (Alpha-1,4-N-acetylglucosaminyltransferase) (Alpha-1,4-galactosyltransferase) (Alpha4Gal-T1) (CD77 synthase) (Globotriaosylceramide synthase) (Gb3 synthase) (P1/Pk synthase) (UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase)
1_MSKPP 6_ DLLLR 11_ LLRGA 16_ PRQRV 21_ CTLFI 26_ IGFKF 31_ TFFVS 36_ IMIYW 41_ HVVGE 46_ PKEKG 51_ QLYNL 56_ PAEIP 61_ CPTLT 66_ PPTPP 71_ SHGPT 76_ PGNIF 81_ FLETS 86_ DRTNP 91_ NFLFM 96_ CSVES 101_ AARTH 106_ PESHV 111_ LVLMK 116_ GLPGG 121_ NASLP 126_ RHLGI 131_ SLLSC 136_ FPNVQ 141_ MLPLD 146_ LRELF 151_ RDTPL 156_ ADWYA 161_ AVQGR 166_ WEPYL 171_ LPVLS 176_ DASRI 181_ ALMWK 186_ FGGIY 191_ LDTDF 196_ IVLKN 201_ LRNLT 206_ NVLGT 211_ QSRYV 216_ LNGAF 221_ LAFER 226_ RHEFM 231_ ALCMR 236_ DFVDH 241_ YNGWI 246_ WGHQG 251_ PQLLT 256_ RVFKK 261_ WCSIR 266_ SLAES 271_ RACRG 276_ VTTLP 281_ PEAFY 286_ PIPWQ 291_ DWKKY 296_ FEDIN 301_ PEELP 306_ RLLSA 311_ TYAVH 316_ VWNKK 321_ SQGTR 326_ FEATS 331_ RALLA 336_ QLHAR 341_ YCPTT 346_HEAMK
1: Catalyzes the transfer of galactose from UDP-alpha-D-galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)) (PubMed:10748143). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (PubMed:10748143). Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes (Probable). Globotriaosylceramide/globoside Gb3Cer in blood and tissue cell membranes is the antigen Pk of blood histogroup P (PubMed:10747952)
2: (Microbial infection) Globotriaosylceramide is one of the cellular ligands for bacterial verotoxins