Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A)
1_MAGLE 6_ LLSDQ 11_ GYRVD 16_ GRRAG 21_ ELRKI 26_ QARMG 31_ VFAQA 36_ DGSAY 41_ IEQGN 46_ TKALA 51_ VVYGP 56_ HEIRG 61_ SRARA 66_ LPDRA 71_ LVNCQ 76_ YSSAT 81_ FSTGE 86_ RKRRP 91_ HGDRK 96_ SCEMG 101_ LQLRQ 106_ TFEAA 111_ ILTQL 116_ HPRSQ 121_ IDIYV 126_ QVLQA 131_ DGGTY 136_ AACVN 141_ AATLA 146_ VLDAG 151_ IPMRD 156_ FVCAC 161_ SAGFV 166_ DGTAL 171_ ADLSH 176_ VEEAA 181_ GGPQL 186_ ALALL 191_ PASGQ 196_ IALLE 201_ MDARL 206_ HEDHL 211_ ERVLE 216_ AAAQA 221_ ARDVH 226_ TLLDR 231_ VVRQH 236_VREAS
1: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs