Solute carrier organic anion transporter family member 1B3 (Liver-specific organic anion transporter 2) (LST-2) (Organic anion transporter 8) (Organic anion-transporting polypeptide 8) (OATP-8) (Solute carrier family 21 member 8)
1_MDQHQ 6_ HLNKT 11_ AESAS 16_ SEKKK 21_ TRRCN 26_ GFKMF 31_ LAALS 36_ FSYIA 41_ KALGG 46_ IIMKI 51_ SITQI 56_ ERRFD 61_ ISSSL 66_ AGLID 71_ GSFEI 76_ GNLLV 81_ IVFVS 86_ YFGSK 91_ LHRPK 96_ LIGIG 101_ CLLMG 106_ TGSIL 111_ TSLPH 116_ FFMGY 121_ YRYSK 126_ ETHIN 131_ PSENS 136_ TSSLS 141_ TCLIN 146_ QTLSF 151_ NGTSP 156_ EIVEK 161_ DCVKE 166_ SGSHM 171_ WIYVF 176_ MGNML 181_ RGIGE 186_ TPIVP 191_ LGISY 196_ IDDFA 201_ KEGHS 206_ SLYLG 211_ SLNAI 216_ GMIGP 221_ VIGFA 226_ LGSLF 231_ AKMYV 236_ DIGYV 241_ DLSTI 246_ RITPK 251_ DSRWV 256_ GAWWL 261_ GFLVS 266_ GLFSI 271_ ISSIP 276_ FFFLP 281_ KNPNK 286_ PQKER 291_ KISLS 296_ LHVLK 301_ TNDDR 306_ NQTAN 311_ LTNQG 316_ KNVTK 321_ NVTGF 326_ FQSLK 331_ SILTN 336_ PLYVI 341_ FLLLT 346_ LLQVS 351_ SFIGS 356_ FTYVF 361_ KYMEQ 366_ QYGQS 371_ ASHAN 376_ FLLGI 381_ ITIPT 386_ VATGM 391_ FLGGF 396_ IIKKF 401_ KLSLV 406_ GIAKF 411_ SFLTS 416_ MISFL 421_ FQLLY 426_ FPLIC 431_ ESKSV 436_ AGLTL 441_ TYDGN 446_ NSVAS 451_ HVDVP 456_ LSYCN 461_ SECNC 466_ DESQW 471_ EPVCG 476_ NNGIT 481_ YLSPC 486_ LAGCK 491_ SSSGI 496_ KKHTV 501_ FYNCS 506_ CVEVT 511_ GLQNR 516_ NYSAH 521_ LGECP 526_ RDNTC 531_ TRKFF 536_ IYVAI 541_ QVINS 546_ LFSAT 551_ GGTTF 556_ ILLTV 561_ KIVQP 566_ ELKAL 571_ AMGFQ 576_ SMVIR 581_ TLGGI 586_ LAPIY 591_ FGALI 596_ DKTCM 601_ KWSTN 606_ SCGAQ 611_ GACRI 616_ YNSVF 621_ FGRVY 626_ LGLSI 631_ ALRFP 636_ ALVLY 641_ IVFIF 646_ AMKKK 651_ FQGKD 656_ TKASD 661_ NERKV 666_ MDEAN 671_ LEFLN 676_ NGEHF 681_ VPSAG 686_ TDSKT 691_ CNLDM 696_QDNAA
1: Mediates the Na(+)-independent uptake of organic anions (PubMed:10779507, PubMed:15159445, PubMed:17412826). Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate), as well as eicosanoid leukotriene C4, prostaglandin E2 and L-thyroxine (T4) (PubMed:10779507, PubMed:11159893, PubMed:12568656, PubMed:15159445, PubMed:17412826, PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). Shows a pH-sensitive substrate specificity towards sulfated steroids, taurocholate and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Involved in the clearance of bile acids and organic anions from the liver (PubMed:22232210). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop (PubMed:22232210). Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition (PubMed:26383540). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can transport HMG-CoA reductase inhibitors (also known as statins) such as pitavastatin, a clinically important class of hypolipidemic drugs (PubMed:15159445). May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel (PubMed:23243220). May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver (PubMed:16624871, PubMed:16627748)