Ubiquitin-conjugating enzyme E2 T (EC 2.3.2.23) (Cell proliferation-inducing gene 50 protein) (E2 ubiquitin-conjugating enzyme T) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T)
1_MQRAS 6_ RLKRE 11_ LHMLA 16_ TEPPP 21_ GITCW 26_ QDKDQ 31_ MDDLR 36_ AQILG 41_ GANTP 46_ YEKGV 51_ FKLEV 56_ IIPER 61_ YPFEP 66_ PQIRF 71_ LTPIY 76_ HPNID 81_ SAGRI 86_ CLDVL 91_ KLPPK 96_ GAWRP 101_ SLNIA 106_ TVLTS 111_ IQLLM 116_ SEPNP 121_ DDPLM 126_ ADISS 131_ EFKYN 136_ KPAFL 141_ KNARQ 146_ WTEKH 151_ ARQKQ 156_ KADEE 161_ EMLDN 166_ LPEAG 171_ DSRVH 176_ NSTQK 181_ RKASQ 186_ LVGIE 191_KKFHP
1: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784). May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386)