CD320 antigen (8D6 antigen) (FDC-signaling molecule 8D6) (FDC-SM-8D6) (Transcobalamin receptor) (TCblR) (CD antigen CD320)
1_MSGGW 6_ MAQVG 11_ AWRTG 16_ ALGLA 21_ LLLLL 26_ GLGLG 31_ LEAAA 36_ SPLST 41_ PTSAQ 46_ AAGPS 51_ SGSCP 56_ PTKFQ 61_ CRTSG 66_ LCVPL 71_ TWRCD 76_ RDLDC 81_ SDGSD 86_ EEECR 91_ IEPCT 96_ QKGQC 101_ PPPPG 106_ LPCPC 111_ TGVSD 116_ CSGGT 121_ DKKLR 126_ NCSRL 131_ ACLAG 136_ ELRCT 141_ LSDDC 146_ IPLTW 151_ RCDGH 156_ PDCPD 161_ SSDEL 166_ GCGTN 171_ EILPE 176_ GDATT 181_ MGPPV 186_ TLESV 191_ TSLRN 196_ ATTMG 201_ PPVTL 206_ ESVPS 211_ VGNAT 216_ SSSAG 221_ DQSGS 226_ PTAYG 231_ VIAAA 236_ AVLSA 241_ SLVTA 246_ TLLLL 251_ SWLRA 256_ QERLR 261_ PLGLL 266_ VAMKE 271_ SLLLS 276_EQKTS
1: Receptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213). Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells (PubMed:10727470). Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631). Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) (PubMed:11418631). CD320 augments the proliferation of PC precursors generated by IL-10 (PubMed:11418631)