tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase) (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP)
1_MPAVL 6_ GFEGS 11_ ANKIG 16_ VGVVR 21_ DGKVL 26_ ANPRR 31_ TYVTP 36_ PGTGF 41_ LPGDT 46_ ARHHR 51_ AVILD 56_ LLQEA 61_ LTESG 66_ LTSQD 71_ IDCIA 76_ YTKGP 81_ GMGAP 86_ LVSVA 91_ VVART 96_ VAQLW 101_ NKPLV 106_ GVNHC 111_ IGHIE 116_ MGRLI 121_ TGATS 126_ PTVLY 131_ VSGGN 136_ TQVIA 141_ YSEHR 146_ YRIFG 151_ ETIDI 156_ AVGNC 161_ LDRFA 166_ RVLKI 171_ SNDPS 176_ PGYNI 181_ EQMAK 186_ RGKKL 191_ VELPY 196_ TVKGM 201_ DVSFS 206_ GILSF 211_ IEDVA 216_ HRMLA 221_ TGECT 226_ PEDLC 231_ FSLQE 236_ TVFAM 241_ LVEIT 246_ ERAMA 251_ HCGSQ 256_ EALIV 261_ GGVGC 266_ NVRLQ 271_ EMMAT 276_ MCQER 281_ GARLF 286_ ATDER 291_ FCIDN 296_ GAMIA 301_ QAGWE 306_ MFRAG 311_ HRTPL 316_ SDSGV 321_ TQRYR 326_TDEVE
1: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity