DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1)
1_MATGA 6_ DVRDI 11_ LELGG 16_ PEGDA 21_ ASGTI 26_ SKKDI 31_ INPDK 36_ KKSKK 41_ SSETL 46_ TFKRP 51_ EGMHR 56_ EVYAL 61_ LYSDK 66_ KDAPP 71_ LLPSD 76_ TGQGY 81_ RTVKA 86_ KLGSK 91_ KVRPW 96_ KWMPF 101_ TNPAR 106_ KDGAM 111_ FFHWR 116_ RAAEE 121_ GKDYP 126_ FARFN 131_ KTVQV 136_ PVYSE 141_ QEYQL 146_ YLHDD 151_ AWTKA 156_ ETDHL 161_ FDLSR 166_ RFDLR 171_ FVVIH 176_ DRYDH 181_ QQFKK 186_ RSVED 191_ LKERY 196_ YHICA 201_ KLANV 206_ RAVPG 211_ TDLKI 216_ PVFDA 221_ GHERR 226_ RKEQL 231_ ERLYN 236_ RTPEQ 241_ VAEEE 246_ YLLQE 251_ LRKIE 256_ ARKKE 261_ REKRS 266_ QDLQK 271_ LITAA 276_ DTTAE 281_ QRRTE 286_ RKAPK 291_ KKLPQ 296_ KKEAE 301_ KPAVP 306_ ETAGI 311_ KFPDF 316_ KSAGV 321_ TLRSQ 326_ RMKLP 331_ SSVGQ 336_ KKIKA 341_ LEQML 346_ LELGV 351_ ELSPT 356_ PTEEL 361_ VHMFN 366_ ELRSD 371_ LVLLY 376_ ELKQA 381_ CANCE 386_ YELQM 391_ LRHRH 396_ EALAR 401_ AGVLG 406_ GPATP 411_ ASGPG 416_ PASAE 421_ PAVTE 426_ PGLGP 431_ DPKDT 436_ IIDVV 441_ GAPLT 446_ PNSRK 451_ RRESA 456_ SSSSS 461_VKKAK
1: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity