Interleukin-23 subunit alpha (IL-23 subunit alpha) (IL-23-A) (Interleukin-23 subunit p19) (IL-23p19)
1_MLGSR 6_ AVMLL 11_ LLLPW 16_ TAQGR 21_ AVPGG 26_ SSPAW 31_ TQCQQ 36_ LSQKL 41_ CTLAW 46_ SAHPL 51_ VGHMD 56_ LREEG 61_ DEETT 66_ NDVPH 71_ IQCGD 76_ GCDPQ 81_ GLRDN 86_ SQFCL 91_ QRIHQ 96_ GLIFY 101_ EKLLG 106_ SDIFT 111_ GEPSL 116_ LPDSP 121_ VGQLH 126_ ASLLG 131_ LSQLL 136_ QPEGH 141_ HWETQ 146_ QIPSL 151_ SPSQP 156_ WQRLL 161_ LRFKI 166_ LRSLQ 171_ AFVAV 176_ AARVF 181_AHGAA
1: Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383). Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4 (PubMed:29287995, PubMed:32474165, PubMed:33606986). This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A (PubMed:12023369). In turn, participates in the early and effective intracellular bacterial clearance (PubMed:32474165). Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells (PubMed:17676044)