Palmitoyltransferase ZDHHC4 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 4) (DHHC-4) (Zinc finger protein 374)
1_MDFLV 6_ LFLFY 11_ LASVL 16_ MGLVL 21_ ICVCS 26_ KTHSL 31_ KGLAR 36_ GGAQI 41_ FSCII 46_ PECLQ 51_ RAVHG 56_ LLHYL 61_ FHTRN 66_ HTFIV 71_ LHLVL 76_ QGMVY 81_ TEYTW 86_ EVFGY 91_ CQELE 96_ LSLHY 101_ LLLPY 106_ LLLGV 111_ NLFFF 116_ TLTCG 121_ TNPGI 126_ ITKAN 131_ ELLFL 136_ HVYEF 141_ DEVMF 146_ PKNVR 151_ CSTCD 156_ LRKPA 161_ RSKHC 166_ SVCNW 171_ CVHRF 176_ DHHCV 181_ WVNNC 186_ IGAWN 191_ IRYFL 196_ IYVLT 201_ LTASA 206_ ATVAI 211_ VSTTF 216_ LVHLV 221_ VMSDL 226_ YQETY 231_ IDDLG 236_ HLHVM 241_ DTVFL 246_ IQYLF 251_ LTFPR 256_ IVFML 261_ GFVVV 266_ LSFLL 271_ GGYLL 276_ FVLYL 281_ AATNQ 286_ TTNEW 291_ YRGDW 296_ AWCQR 301_ CPLVA 306_ WPPSA 311_ EPQVH 316_ RNIHS 321_ HGLRS 326_ NLQEI 331_ FLPAF 336_PCHER
1: Palmitoyltransferase that catalyzes the addition of palmitate onto protein substrates including the D(2) dopamine receptor DRD2, GSK3B or MAVS. Mediates GSK3B palmitoylation to prevent its AKT1-mediated phosphorylation leading to activation of the STAT3 signaling pathway (PubMed:35606353). Also catalyzes MAVS palmitoylation which promotes its stabilization and activation by inhibiting 'Lys-48'- but facilitating 'Lys-63'-linked ubiquitination (PubMed:38016475)