Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)
1_MTLLW 6_ CVVSL 11_ YFYGI 16_ LQSDA 21_ SERCD 26_ DWGLD 31_ TMRQI 36_ QVFED 41_ EPARI 46_ KCPLF 51_ EHFLK 56_ FNYST 61_ AHSAG 66_ LTLIW 71_ YWTRQ 76_ DRDLE 81_ EPINF 86_ RLPEN 91_ RISKE 96_ KDVLW 101_ FRPTL 106_ LNDTG 111_ NYTCM 116_ LRNTT 121_ YCSKV 126_ AFPLE 131_ VVQKD 136_ SCFNS 141_ PMKLP 146_ VHKLY 151_ IEYGI 156_ QRITC 161_ PNVDG 166_ YFPSS 171_ VKPTI 176_ TWYMG 181_ CYKIQ 186_ NFNNV 191_ IPEGM 196_ NLSFL 201_ IALIS 206_ NNGNY 211_ TCVVT 216_ YPENG 221_ RTFHL 226_ TRTLT 231_ VKVVG 236_ SPKNA 241_ VPPVI 246_ HSPND 251_ HVVYE 256_ KEPGE 261_ ELLIP 266_ CTVYF 271_ SFLMD 276_ SRNEV 281_ WWTID 286_ GKKPD 291_ DITID 296_ VTINE 301_ SISHS 306_ RTEDE 311_ TRTQI 316_ LSIKK 321_ VTSED 326_ LKRSY 331_ VCHAR 336_ SAKGE 341_ VAKAA 346_ KVKQK 351_ VPAPR 356_ YTVEL 361_ ACGFG 366_ ATVLL 371_ VVILI 376_ VVYHV 381_ YWLEM 386_ VLFYR 391_ AHFGT 396_ DETIL 401_ DGKEY 406_ DIYVS 411_ YARNA 416_ EEEEF 421_ VLLTL 426_ RGVLE 431_ NEFGY 436_ KLCIF 441_ DRDSL 446_ PGGIV 451_ TDETL 456_ SFIQK 461_ SRRLL 466_ VVLSP 471_ NYVLQ 476_ GTQAL 481_ LELKA 486_ GLENM 491_ ASRGN 496_ INVIL 501_ VQYKA 506_ VKETK 511_ VKELK 516_ RAKTV 521_ LTVIK 526_ WKGEK 531_ SKYPQ 536_ GRFWK 541_ QLQVA 546_ MPVKK 551_ SPRRS 556_ SSDEQ 561_GLSYS
1: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable)
2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity)
3: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity)