NADPH oxidase 4 (EC 1.6.3.-) (Kidney oxidase-1) (KOX-1) (Kidney superoxide-producing NADPH oxidase) (Renal NAD(P)H-oxidase)
1_MAVSW 6_ RSWLA 11_ NEGVK 16_ HLCLF 21_ IWLSM 26_ NVLLF 31_ WKTFL 36_ LYNQG 41_ PEYHY 46_ LHQML 51_ GLGLC 56_ LSRAS 61_ ASVLN 66_ LNCSL 71_ ILLPM 76_ CRTLL 81_ AYLRG 86_ SQKVP 91_ SRRTR 96_ RLLDK 101_ SRTFH 106_ ITCGV 111_ TICIF 116_ SGVHV 121_ AAHLV 126_ NALNF 131_ SVNYS 136_ EDFVE 141_ LNAAR 146_ YRDED 151_ PRKLL 156_ FTTVP 161_ GLTGV 166_ CMVVV 171_ LFLMI 176_ TASTY 181_ AIRVS 186_ NYDIF 191_ WYTHN 196_ LFFVF 201_ YMLLT 206_ LHVSG 211_ GLLKY 216_ QTNLD 221_ THPPG 226_ CISLN 231_ RTSSQ 236_ NISLP 241_ EYFSE 246_ HFHEP 251_ FPEGF 256_ SKPAE 261_ FTQHK 266_ FVKIC 271_ MEEPR 276_ FQANF 281_ PQTWL 286_ WISGP 291_ LCLYC 296_ AERLY 301_ RYIRS 306_ NKPVT 311_ IISVM 316_ SHPSD 321_ VMEIR 326_ MVKEN 331_ FKARP 336_ GQYIT 341_ LHCPS 346_ VSALE 351_ NHPFT 356_ LTMCP 361_ TETKA 366_ TFGVH 371_ LKIVG 376_ DWTER 381_ FRDLL 386_ LPPSS 391_ QDSEI 396_ LPFIQ 401_ SRNYP 406_ KLYID 411_ GPFGS 416_ PFEES 421_ LNYEV 426_ SLCVA 431_ GGIGV 436_ TPFAS 441_ ILNTL 446_ LDDWK 451_ PYKLR 456_ RLYFI 461_ WVCRD 466_ IQSFR 471_ WFADL 476_ LCMLH 481_ NKFWQ 486_ ENRPD 491_ YVNIQ 496_ LYLSQ 501_ TDGIQ 506_ KIIGE 511_ KYHAL 516_ NSRLF 521_ IGRPR 526_ WKLLF 531_ DEIAK 536_ YNRGK 541_ TVGVF 546_ CCGPN 551_ SLSKT 556_ LHKLS 561_ NQNNS 566_ YGTRF 571_EYNKE
1: NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2 (PubMed:14966267, PubMed:15356101, PubMed:15927447, PubMed:21343298, PubMed:25062272). Can also catalyze to a smaller extent, the reduction of oxygen to superoxide (PubMed:10869423, PubMed:11032835, PubMed:15155719, PubMed:15572675, PubMed:15927447, PubMed:16019190, PubMed:16179589, PubMed:16230378, PubMed:16324151, PubMed:25062272). May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity (PubMed:16019190). May regulate insulin signaling cascade (PubMed:14966267). May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (PubMed:15356101, PubMed:15572675). May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation (PubMed:16324151). Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release (PubMed:39909992)
2: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:15721269, PubMed:23393389). Involved in redox signaling in vascular cells (PubMed:23393389). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage (PubMed:23393389)
3: Lacks superoxide-generating NADPH oxidase activity