Interleukin-26 (IL-26) (Protein AK155)
1_MLVNF 6_ ILRCG 11_ LLLVT 16_ LSLAI 21_ AKHKQ 26_ SSFTK 31_ SCYPR 36_ GTLSQ 41_ AVDAL 46_ YIKAA 51_ WLKAT 56_ IPEDR 61_ IKNIR 66_ LLKKK 71_ TKKQF 76_ MKNCQ 81_ FQEQL 86_ LSFFM 91_ EDVFG 96_ QLQLQ 101_ GCKKI 106_ RFVED 111_ FHSLR 116_ QKLSH 121_ CISCA 126_ SSARE 131_ MKSIT 136_ RMKRI 141_ FYRIG 146_ NKGIY 151_ KAISE 156_ LDILL 161_ SWIKK 166_LLESS
1: May play a role in local mechanisms of mucosal immunity and seems to have a pro-inflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin