Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1)
1_MGKKH 6_ KKHKS 11_ DKHLY 16_ EEYVE 21_ KPLKL 26_ VLKVG 31_ GNEVT 36_ ELSTG 41_ SSGHD 46_ SSLFE 51_ DKNDH 56_ DKHKD 61_ RKRKK 66_ RKKGE 71_ KQIPG 76_ EEKGR 81_ KRRRV 86_ KEDKK 91_ KRDRD 96_ RVENE 101_ AEKDL 106_ QCHAP 111_ VRLDL 116_ PPEKP 121_ LTSSL 126_ AKQEE 131_ VEQTP 136_ LQEAL 141_ NQLMR 146_ QLQRK 151_ DPSAF 156_ FSFPV 161_ TDFIA 166_ PGYSM 171_ IIKHP 176_ MDFST 181_ MKEKI 186_ KNNDY 191_ QSIEE 196_ LKDNF 201_ KLMCT 206_ NAMIY 211_ NKPET 216_ IYYKA 221_ AKKLL 226_ HSGMK 231_ ILSQE 236_ RIQSL 241_ KQSID 246_ FMADL 251_ QKTRK 256_ QKDGT 261_ DTSQS 266_ GEDGG 271_ CWQRE 276_ REDSG 281_ DAEAH 286_ AFKSP 291_ SKENK 296_ KKDKD 301_ MLEDK 306_ FKSNN 311_ LEREQ 316_ EQLDR 321_ IVKES 326_ GGKLT 331_ RRLVN 336_ SQCEF 341_ ERRKP 346_ DGTTT 351_ LGLLH 356_ PVDPI 361_ VGEPG 366_ YCPVR 371_ LGMTT 376_ GRLQS 381_ GVNTL 386_ QGFKE 391_ DKRNK 396_ VTPVL 401_ YLNYG 406_ PYSSY 411_ APHYD 416_ STFAN 421_ ISKDD 426_ SDLIY 431_ STYGE 436_ DSDLP 441_ SDFSI 446_ HEFLA 451_ TCQDY 456_ PYVMA 461_ DSLLD 466_ VLTKG 471_ GHSRT 476_ LQEME 481_ MSLPE 486_ DEGHT 491_ RTLDT 496_ AKEME 501_ ITEVE 506_ PPGRL 511_ DSSTQ 516_ DRLIA 521_ LKAVT 526_ NFGVP 531_ VEVFD 536_ SEEAE 541_ IFQKK 546_ LDETT 551_ RLLRE 556_ LQEAQ 561_ NERLS 566_ TRPPP 571_ NMICL 576_ LGPSY 581_ REMHL 586_ AEQVT 591_ NNLKE 596_ LAQQV 601_ TPGDI 606_ VSTYG 611_ VRKAM 616_ GISIP 621_ SPVME 626_ NNFVD 631_ LTEDT 636_ EEPKK 641_ TDVAE 646_CGPGG
1: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase