Inward rectifier potassium channel 16 (Inward rectifier K(+) channel Kir5.1) (Potassium channel, inwardly rectifying subfamily J member 16)
1_MSYYG 6_ SSYHI 11_ INADA 16_ KYPGY 21_ PPEHI 26_ IAEKR 31_ RARRR 36_ LLHKD 41_ GSCNV 46_ YFKHI 51_ FGEWG 56_ SYVVD 61_ IFTTL 66_ VDTKW 71_ RHMFV 76_ IFSLS 81_ YILSW 86_ LIFGS 91_ VFWLI 96_ AFHHG 101_ DLLND 106_ PDITP 111_ CVDNV 116_ HSFTG 121_ AFLFS 126_ LETQT 131_ TIGYG 136_ YRCVT 141_ EECSV 146_ AVLMV 151_ ILQSI 156_ LSCII 161_ NTFII 166_ GAALA 171_ KMATA 176_ RKRAQ 181_ TIRFS 186_ YFALI 191_ GMRDG 196_ KLCLM 201_ WRIGD 206_ FRPNH 211_ VVEGT 216_ VRAQL 221_ LRYTE 226_ DSEGR 231_ MTMAF 236_ KDLKL 241_ VNDQI 246_ ILVTP 251_ VTIVH 256_ EIDHE 261_ SPLYA 266_ LDRKA 271_ VAKDN 276_ FEILV 281_ TFIYT 286_ GDSTG 291_ TSHQS 296_ RSSYV 301_ PREIL 306_ WGHRF 311_ NDVLE 316_ VKRKY 321_ YKVNC 326_ LQFEG 331_ SVEVY 336_ APFCS 341_ AKQLD 346_ WKDQQ 351_ LHIEK 356_ APPVR 361_ ESCTS 366_ DTKAR 371_ RRSFS 376_ AVAIV 381_ SSCEN 386_ PEETT 391_ TSATH 396_ EYRET 401_ PYQKA 406_ LLTLN 411_RISVE
1: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201)