Acyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (EC 3.1.2.-) (Hotdog-fold thioesterase superfamily member 2) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Thioesterase superfamily member 2) (THEM2) [Cleaved into: Acyl-coenzyme A thioesterase 13, N-terminally processed]
1_MTSMT 6_ QSLRE 11_ VIKAM 16_ TKARN 21_ FERVL 26_ GKITL 31_ VSAAP 36_ GKVIC 41_ EMKVE 46_ EEHTN 51_ AIGTL 56_ HGGLT 61_ ATLVD 66_ NISTM 71_ ALLCT 76_ ERGAP 81_ GVSVD 86_ MNITY 91_ MSPAK 96_ LGEDI 101_ VITAH 106_ VLKQG 111_ KTLAF 116_ TSVDL 121_ TNKAT 126_ GKLIA 131_QGRHT
1: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16934754, PubMed:19170545). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (By similarity) (PubMed:16934754, PubMed:19170545). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity) (PubMed:16934754, PubMed:19170545). May play a role in controlling adaptive thermogenesis (By similarity)