NLR family CARD domain-containing protein 4 (CARD, LRR, and NACHT-containing protein) (CED-4-like protein Clan) (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)
1_MNFIK 6_ DNSRA 11_ LIQRM 16_ GMTVI 21_ KQITD 26_ DLFVW 31_ NVLNR 36_ EEVNI 41_ ICCEK 46_ VEQDA 51_ ARGII 56_ HMILK 61_ KGSES 66_ CNLFL 71_ KSLKE 76_ WNYPL 81_ FQDLN 86_ GQSLF 91_ HQTSE 96_ GDLDD 101_ LAQDL 106_ KDLYH 111_ TPSFL 116_ NFYPL 121_ GEDID 126_ IIFNL 131_ KSTFT 136_ EPVLW 141_ RKDQH 146_ HHRVE 151_ QLTLN 156_ GLLQA 161_ LQSPC 166_ IIEGE 171_ SGKGK 176_ STLLQ 181_ RIAML 186_ WGSGK 191_ CKALT 196_ KFKFV 201_ FFLRL 206_ SRAQG 211_ GLFET 216_ LCDQL 221_ LDIPG 226_ TIRKQ 231_ TFMAM 236_ LLKLR 241_ QRVLF 246_ LLDGY 251_ NEFKP 256_ QNCPE 261_ IEALI 266_ KENHR 271_ FKNMV 276_ IVTTT 281_ TECLR 286_ HIRQF 291_ GALTA 296_ EVGDM 301_ TEDSA 306_ QALIR 311_ EVLIK 316_ ELAEG 321_ LLLQI 326_ QKSRC 331_ LRNLM 336_ KTPLF 341_ VVITC 346_ AIQMG 351_ ESEFH 356_ SHTQT 361_ TLFHT 366_ FYDLL 371_ IQKNK 376_ HKHKG 381_ VAASD 386_ FIRSL 391_ DHCGD 396_ LALEG 401_ VFSHK 406_ FDFEL 411_ QDVSS 416_ VNEDV 421_ LLTTG 426_ LLCKY 431_ TAQRF 436_ KPKYK 441_ FFHKS 446_ FQEYT 451_ AGRRL 456_ SSLLT 461_ SHEPE 466_ EVTKG 471_ NGYLQ 476_ KMVSI 481_ SDITS 486_ TYSSL 491_ LRYTC 496_ GSSVE 501_ ATRAV 506_ MKHLA 511_ AVYQH 516_ GCLLG 521_ LSIAK 526_ RPLWR 531_ QESLQ 536_ SVKNT 541_ TEQEI 546_ LKAIN 551_ INSFV 556_ ECGIH 561_ LYQES 566_ TSKSA 571_ LSQEF 576_ EAFFQ 581_ GKSLY 586_ INSGN 591_ IPDYL 596_ FDFFE 601_ HLPNC 606_ ASALD 611_ FIKLD 616_ FYGGA 621_ MASWE 626_ KAAED 631_ TGGIH 636_ MEEAP 641_ ETYIP 646_ SRAVS 651_ LFFNW 656_ KQEFR 661_ TLEVT 666_ LRDFS 671_ KLNKQ 676_ DIRYL 681_ GKIFS 686_ SATSL 691_ RLQIK 696_ RCAGV 701_ AGSLS 706_ LVLST 711_ CKNIY 716_ SLMVE 721_ ASPLT 726_ IEDER 731_ HITSV 736_ TNLKT 741_ LSIHD 746_ LQNQR 751_ LPGGL 756_ TDSLG 761_ NLKNL 766_ TKLIM 771_ DNIKM 776_ NEEDA 781_ IKLAE 786_ GLKNL 791_ KKMCL 796_ FHLTH 801_ LSDIG 806_ EGMDY 811_ IVKSL 816_ SSEPC 821_ DLEEI 826_ QLVSC 831_ CLSAN 836_ AVKIL 841_ AQNLH 846_ NLVKL 851_ SILDL 856_ SENYL 861_ EKDGN 866_ EALHE 871_ LIDRM 876_ NVLEQ 881_ LTALM 886_ LPWGC 891_ DVQGS 896_ LSSLL 901_ KHLEE 906_ VPQLV 911_ KLGLK 916_ NWRLT 921_ DTEIR 926_ ILGAF 931_ FGKNP 936_ LKNFQ 941_ QLNLA 946_ GNRVS 951_ SDGWL 956_ AFMGV 961_ FENLK 966_ QLVFF 971_ DFSTK 976_ EFLPD 981_ PALVR 986_ KLSQV 991_ LSKLT 996_ FLQEA 1001_ RLVGW 1006_ QFDDD 1011_ DLSVI 1016_TGAFK
1: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity)