Synembryn-A (Protein Ric-8A)
1_MEPRA 6_ VAEAV 11_ ETGEE 16_ DVIME 21_ ALRSY 26_ NQEHS 31_ QSFTF 36_ DDAQQ 41_ EDRKR 46_ LAELL 51_ VSVLE 56_ QGLPP 61_ SHRVI 66_ WLQSV 71_ RILSR 76_ DRNCL 81_ DPFTS 86_ RQSLQ 91_ ALACY 96_ ADISV 101_ SEGSV 106_ PESAD 111_ MDVVL 116_ ESLKC 121_ LCNLV 126_ LSSPV 131_ AQMLA 136_ AEARL 141_ VVKLT 146_ ERVGL 151_ YRERS 156_ FPHDV 161_ QFFDL 166_ RLLFL 171_ LTALR 176_ TDVRQ 181_ QLFQE 186_ LKGVR 191_ LLTDT 196_ LELTL 201_ GVTPE 206_ GNPPP 211_ TLLPS 216_ QETER 221_ AMEIL 226_ KVLFN 231_ ITLDS 236_ IKGEV 241_ DEEDA 246_ ALYRH 251_ LGTLL 256_ RHCVM 261_ IATAG 266_ DRTEE 271_ FHGHA 276_ VNLLG 281_ NLPLK 286_ CLDVL 291_ LTLEP 296_ HGDST 301_ EFMGV 306_ NMDVI 311_ RALLI 316_ FLEKR 321_ LHKTH 326_ RLKES 331_ VAPVL 336_ SVLTE 341_ CARMH 346_ RPARK 351_ FLKAQ 356_ VLPPL 361_ RDVRT 366_ RPEVG 371_ EMLRN 376_ KLVRL 381_ MTHLD 386_ TDVKR 391_ VAAEF 396_ LFVLC 401_ SESVP 406_ RFIKY 411_ TGYGN 416_ AAGLL 421_ AARGL 426_ MAGGR 431_ PEGQY 436_ SEDED 441_ TDTDE 446_ YKEAK 451_ ASINP 456_ VTGRV 461_ EEKPP 466_ NPMEG 471_ MTEEQ 476_ KEHEA 481_ MKLVT 486_ MFDKL 491_ SRNRV 496_ IQPMG 501_ MSPRG 506_ HLTSL 511_ QDAMC 516_ ETMEQ 521_ QLSSD 526_PDSDP
1: Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (By similarity). Does not fold G(s) G-alpha proteins GNAS nor GNAL (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (PubMed:16629901)