Complement component C1q receptor (C1q/MBL/SPA receptor) (C1qR) (C1qR(p)) (C1qRp) (CDw93) (Complement component 1 q subcomponent receptor 1) (Matrix-remodeling-associated protein 4) (CD antigen CD93)
1_MATSM 6_ GLLLL 11_ LLLLL 16_ TQPGA 21_ GTGAD 26_ TEAVV 31_ CVGTA 36_ CYTAH 41_ SGKLS 46_ AAEAQ 51_ NHCNQ 56_ NGGNL 61_ ATVKS 66_ KEEAQ 71_ HVQRV 76_ LAQLL 81_ RREAA 86_ LTARM 91_ SKFWI 96_ GLQRE 101_ KGKCL 106_ DPSLP 111_ LKGFS 116_ WVGGG 121_ EDTPY 126_ SNWHK 131_ ELRNS 136_ CISKR 141_ CVSLL 146_ LDLSQ 151_ PLLPS 156_ RLPKW 161_ SEGPC 166_ GSPGS 171_ PGSNI 176_ EGFVC 181_ KFSFK 186_ GMCRP 191_ LALGG 196_ PGQVT 201_ YTTPF 206_ QTTSS 211_ SLEAV 216_ PFASA 221_ ANVAC 226_ GEGDK 231_ DETQS 236_ HYFLC 241_ KEKAP 246_ DVFDW 251_ GSSGP 256_ LCVSP 261_ KYGCN 266_ FNNGG 271_ CHQDC 276_ FEGGD 281_ GSFLC 286_ GCRPG 291_ FRLLD 296_ DLVTC 301_ ASRNP 306_ CSSSP 311_ CRGGA 316_ TCVLG 321_ PHGKN 326_ YTCRC 331_ PQGYQ 336_ LDSSQ 341_ LDCVD 346_ VDECQ 351_ DSPCA 356_ QECVN 361_ TPGGF 366_ RCECW 371_ VGYEP 376_ GGPGE 381_ GACQD 386_ VDECA 391_ LGRSP 396_ CAQGC 401_ TNTDG 406_ SFHCS 411_ CEEGY 416_ VLAGE 421_ DGTQC 426_ QDVDE 431_ CVGPG 436_ GPLCD 441_ SLCFN 446_ TQGSF 451_ HCGCL 456_ PGWVL 461_ APNGV 466_ SCTMG 471_ PVSLG 476_ PPSGP 481_ PDEED 486_ KGEKE 491_ GSTVP 496_ RAATA 501_ SPTRG 506_ PEGTP 511_ KATPT 516_ TSRPS 521_ LSSDA 526_ PITSA 531_ PLKML 536_ APSGS 541_ PGVWR 546_ EPSIH 551_ HATAA 556_ SGPQE 561_ PAGGD 566_ SSVAT 571_ QNNDG 576_ TDGQK 581_ LLLFY 586_ ILGTV 591_ VAILL 596_ LLALA 601_ LGLLV 606_ YRKRR 611_ AKREE 616_ KKEKK 621_ PQNAA 626_ DSYSW 631_ VPERA 636_ ESRAM 641_ ENQYS 646_PTPGT
1: Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2) (PubMed:7977768). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis (PubMed:24809468). Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration (PubMed:26848865). Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands (PubMed:28671670, PubMed:36265539, PubMed:38218180). Both ligands play a non-redundant role in CD93-mediated endothelial cell function (PubMed:38218180). Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function (By similarity)