Polyamine-transporting ATPase 13A2 (EC 7.6.2.-)
1_MSADS 6_ SPLVG 11_ STPTG 16_ YGTLT 21_ IGTSI 26_ DPLSS 31_ SVSSV 36_ RLSGY 41_ CGSPW 46_ RVIGY 51_ HVVVW 56_ MMAGI 61_ PLLLF 66_ RWKPL 71_ WGVRL 76_ RLRPC 81_ NLAHA 86_ ETLVI 91_ EIRDK 96_ EDSSW 101_ QLFTV 106_ QVQTE 111_ AIGEG 116_ SLEPS 121_ PQSQA 126_ EDGRS 131_ QAAVG 136_ AVPEG 141_ AWKDT 146_ AQLHK 151_ SEEAV 156_ SVGQK 161_ RVLRY 166_ YLFQG 171_ QRYIW 176_ IETQQ 181_ AFYQV 186_ SLLDH 191_ GRSCD 196_ DVHRS 201_ RHGLS 206_ LQDQM 211_ VRKAI 216_ YGPNV 221_ ISIPV 226_ KSYPQ 231_ LLVDE 236_ ALNPY 241_ YGFQA 246_ FSIAL 251_ WLADH 256_ YYWYA 261_ LCIFL 266_ ISSIS 271_ ICLSL 276_ YKTRK 281_ QSQTL 286_ RDMVK 291_ LSMRV 296_ CVCRP 301_ GGEEE 306_ WVDSS 311_ ELVPG 316_ DCLVL 321_ PQEGG 326_ LMPCD 331_ AALVA 336_ GECMV 341_ NESSL 346_ TGESI 351_ PVLKT 356_ ALPEG 361_ LGPYC 366_ AETHR 371_ RHTLF 376_ CGTLI 381_ LQARA 386_ YVGPH 391_ VLAVV 396_ TRTGF 401_ CTAKG 406_ GLVSS 411_ ILHPR 416_ PINFK 421_ FYKHS 426_ MKFVA 431_ ALSVL 436_ ALLGT 441_ IYSIF 446_ ILYRN 451_ RVPLN 456_ EIVIR 461_ ALDLV 466_ TVVVP 471_ PALPA 476_ AMTVC 481_ TLYAQ 486_ SRLRR 491_ QGIFC 496_ IHPLR 501_ INLGG 506_ KLQLV 511_ CFDKT 516_ GTLTE 521_ DGLDV 526_ MGVVP 531_ LKGQA 536_ FLPLV 541_ PEPRR 546_ LPVGP 551_ LLRAL 556_ ATCHA 561_ LSRLQ 566_ DTPVG 571_ DPMDL 576_ KMVES 581_ TGWVL 586_ EEEPA 591_ ADSAF 596_ GTQVL 601_ AVMRP 606_ PLWEP 611_ QLQAM 616_ EEPPV 621_ PVSVL 626_ HRFPF 631_ SSALQ 636_ RMSVV 641_ VAWPG 646_ ATQPE 651_ AYVKG 656_ SPELV 661_ AGLCN 666_ PETVP 671_ TDFAQ 676_ MLQSY 681_ TAAGY 686_ RVVAL 691_ ASKPL 696_ PTVPS 701_ LEAAQ 706_ QLTRD 711_ TVEGD 716_ LSLLG 721_ LLVMR 726_ NLLKP 731_ QTTPV 736_ IQALR 741_ RTRIR 746_ AVMVT 751_ GDNLQ 756_ TAVTV 761_ ARGCG 766_ MVAPQ 771_ EHLII 776_ VHATH 781_ PERGQ 786_ PASLE 791_ FLPME 796_ SPTAV 801_ NGVKD 806_ PDQAA 811_ SYTVE 816_ PDPRS 821_ RHLAL 826_ SGPTF 831_ GIIVK 836_ HFPKL 841_ LPKVL 846_ VQGTV 851_ FARMA 856_ PEQKT 861_ ELVCE 866_ LQKLQ 871_ YCVGM 876_ CGDGA 881_ NDCGA 886_ LKAAD 891_ VGISL 896_ SQAEA 901_ SVVSP 906_ FTSSM 911_ ASIEC 916_ VPMVI 921_ REGRC 926_ SLDTS 931_ FSVFK 936_ YMALY 941_ SLTQF 946_ ISVLI 951_ LYTIN 956_ TNLGD 961_ LQFLA 966_ IDLVI 971_ TTTVA 976_ VLMSR 981_ TGPAL 986_ VLGRV 991_ RPPGA 996_ LLSVP 1001_ VLSSL 1006_ LLQMV 1011_ LVTGV 1016_ QLGGY 1021_ FLTLA 1026_ QPWFV 1031_ PLNRT 1036_ VAAPD 1041_ NLPNY 1046_ ENTVV 1051_ FSLSS 1056_ FQYLI 1061_ LAAAV 1066_ SKGAP 1071_ FRRPL 1076_ YTNVP 1081_ FLVAL 1086_ ALLSS 1091_ VLVGL 1096_ VLVPG 1101_ LLQGP 1106_ LALRN 1111_ ITDTG 1116_ FKLLL 1121_ LGLVT 1126_ LNFVG 1131_ AFMLE 1136_ SVLDQ 1141_ CLPAC 1146_ LRRLR 1151_ PKRAS 1156_ KKRFK 1161_ QLERE 1166_ LAEQP 1171_WPPLP
1: ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine (PubMed:31996848). Also stimulates cellular uptake of polyamines and protects against polyamine toxicity (PubMed:31996848). Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (PubMed:22186024). Contributes to cellular zinc homeostasis (PubMed:24603074). Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress (PubMed:26134396). Required for proper lysosomal and mitochondrial maintenance (PubMed:22296644, PubMed:28137957). Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels (PubMed:27278822). Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141). Promotes secretion of exosomes as well as secretion of SCNA via exosomes (PubMed:24603074, PubMed:25392495). Plays a role in lipid homeostasis (PubMed:31132336)