SLAM family member 7 (CD2 subset 1) (CD2-like receptor-activating cytotoxic cells) (CRACC) (Membrane protein FOAP-12) (Novel Ly9) (Protein 19A) (CD antigen CD319)
1_MAGSP 6_ TCLTL 11_ IYILW 16_ QLTGS 21_ AASGP 26_ VKELV 31_ GSVGG 36_ AVTFP 41_ LKSKV 46_ KQVDS 51_ IVWTF 56_ NTTPL 61_ VTIQP 66_ EGGTI 71_ IVTQN 76_ RNRER 81_ VDFPD 86_ GGYSL 91_ KLSKL 96_ KKNDS 101_ GIYYV 106_ GIYSS 111_ SLQQP 116_ STQEY 121_ VLHVY 126_ EHLSK 131_ PKVTM 136_ GLQSN 141_ KNGTC 146_ VTNLT 151_ CCMEH 156_ GEEDV 161_ IYTWK 166_ ALGQA 171_ ANESH 176_ NGSIL 181_ PISWR 186_ WGESD 191_ MTFIC 196_ VARNP 201_ VSRNF 206_ SSPIL 211_ ARKLC 216_ EGAAD 221_ DPDSS 226_ MVLLC 231_ LLLVP 236_ LLLSL 241_ FVLGL 246_ FLWFL 251_ KRERQ 256_ EEYIE 261_ EKKRV 266_ DICRE 271_ TPNIC 276_ PHSGE 281_ NTEYD 286_ TIPHT 291_ NRTIL 296_ KEDPA 301_ NTVYS 306_ TVEIP 311_ KKMEN 316_ PHSLL 321_ TMPDT 326_PRLFA
1: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Also acts inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528)
2: Isoform 3 does not mediate any NK cell activation