Signal peptide, CUB and EGF-like domain-containing protein 2 (Protein CEGP1) (Scube/You)
1_MGVAG 6_ RNRPG 11_ AAWAV 16_ LLLLL 21_ LLPPL 26_ LLLAG 31_ AVPPG 36_ RGRAA 41_ GPQED 46_ VDECA 51_ QGLDD 56_ CHADA 61_ LCQNT 66_ PTSYK 71_ CSCKP 76_ GYQGE 81_ GRQCE 86_ DIDEC 91_ GNELN 96_ GGCVH 101_ DCLNI 106_ PGNYR 111_ CTCFD 116_ GFMLA 121_ HDGHN 126_ CLDVD 131_ ECLEN 136_ NGGCQ 141_ HTCVN 146_ VMGSY 151_ ECCCK 156_ EGFFL 161_ SDNQH 166_ TCIHR 171_ SEEGL 176_ SCMNK 181_ DHGCS 186_ HICKE 191_ APRGS 196_ VACEC 201_ RPGFE 206_ LAKNQ 211_ RDCIL 216_ TCNHG 221_ NGGCQ 226_ HSCDD 231_ TADGP 236_ ECSCH 241_ PQYKM 246_ HTDGR 251_ SCLER 256_ EDTVL 261_ EVTES 266_ NTTSV 271_ VDGDK 276_ RVKRR 281_ LLMET 286_ CAVNN 291_ GGCDR 296_ TCKDT 301_ STGVH 306_ CSCPV 311_ GFTLQ 316_ LDGKT 321_ CKDID 326_ ECQTR 331_ NGGCD 336_ HFCKN 341_ IVGSF 346_ DCGCK 351_ KGFKL 356_ LTDEK 361_ SCQDV 366_ DECSL 371_ DRTCD 376_ HSCIN 381_ HPGTF 386_ ACACN 391_ RGYTL 396_ YGFTH 401_ CGDTN 406_ ECSIN 411_ NGGCQ 416_ QVCVN 421_ TVGSY 426_ ECQCH 431_ PGYKL 436_ HWNKK 441_ DCVEV 446_ KGLLP 451_ TSVSP 456_ RVSLH 461_ CGKSG 466_ GGDGC 471_ FLRCH 476_ SGIHL 481_ SSDVT 486_ TIRTS 491_ VTFKL 496_ NEGKC 501_ SLKNA 506_ ELFPE 511_ GLRPA 516_ LPEKH 521_ SSVKE 526_ SFRYV 531_ NLTCS 536_ SGKQV 541_ PGAPG 546_ RPSTP 551_ KEMFI 556_ TVEFE 561_ LETNQ 566_ KEVTA 571_ SCDLS 576_ CIVKR 581_ TEKRL 586_ RKAIR 591_ TLRKA 596_ VHREQ 601_ FHLQL 606_ SGMNL 611_ DVAKK 616_ PPRTS 621_ ERQAE 626_ SCGVG 631_ QGHAE 636_ NQCVS 641_ CRAGT 646_ YYDGA 651_ RERCI 656_ LCPNG 661_ TFQNE 666_ EGQMT 671_ CEPCP 676_ RPGNS 681_ GALKT 686_ PEAWN 691_ MSECG 696_ GLCQP 701_ GEYSA 706_ DGFAP 711_ CQLCA 716_ LGTFQ 721_ PEAGR 726_ TSCFP 731_ CGGGL 736_ ATKHQ 741_ GATSF 746_ QDCET 751_ RVQCS 756_ PGHFY 761_ NTTTH 766_ RCIRC 771_ PVGTY 776_ QPEFG 781_ KNNCV 786_ SCPGN 791_ TTTDF 796_ DGSTN 801_ ITQCK 806_ NRRCG 811_ GELGD 816_ FTGYI 821_ ESPNY 826_ PGNYP 831_ ANTEC 836_ TWTIN 841_ PPPKR 846_ RILIV 851_ VPEIF 856_ LPIED 861_ DCGDY 866_ LVMRK 871_ TSSSN 876_ SVTTY 881_ ETCQT 886_ YERPI 891_ AFTSR 896_ SKKLW 901_ IQFKS 906_ NEGNS 911_ ARGFQ 916_ VPYVT 921_ YDEDY 926_ QELIE 931_ DIVRD 936_ GRLYA 941_ SENHQ 946_ EILKD 951_ KKLIK 956_ ALFDV 961_ LAHPQ 966_ NYFKY 971_ TAQES 976_ REMFP 981_ RSFIR 986_ LLRSK 991_VSRFL
1: Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22677548, PubMed:22902404). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687)