Serine protease inhibitor Kazal-type 5 (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Cleaved into: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665]
1_MKIAT 6_ VSVLL 11_ PLALC 16_ LIQDA 21_ ASKNE 26_ DQEMC 31_ HEFQA 36_ FMKNG 41_ KLFCP 46_ QDKKF 51_ FQSLD 56_ GIMFI 61_ NKCAT 66_ CKMIL 71_ EKEAK 76_ SQKRA 81_ RHLAR 86_ APKAT 91_ APTEL 96_ NCDDF 101_ KKGER 106_ DGDFI 111_ CPDYY 116_ EAVCG 121_ TDGKT 126_ YDNRC 131_ ALCAE 136_ NAKTG 141_ SQIGV 146_ KSEGE 151_ CKSSN 156_ PEQDV 161_ CSAFR 166_ PFVRD 171_ GRLGC 176_ TREND 181_ PVLGP 186_ DGKTH 191_ GNKCA 196_ MCAEL 201_ FLKEA 206_ ENAKR 211_ EGETR 216_ IRRNA 221_ EKDFC 226_ KEYEK 231_ QVRNG 236_ RLFCT 241_ RESDP 246_ VRGPD 251_ GRMHG 256_ NKCAL 261_ CAEIF 266_ KQRFS 271_ EENSK 276_ TDQNL 281_ GKAEE 286_ KTKVK 291_ REIVK 296_ LCSQY 301_ QNQAK 306_ NGILF 311_ CTREN 316_ DPIRG 321_ PDGKM 326_ HGNLC 331_ SMCQA 336_ YFQAE 341_ NEEKK 346_ KAEAR 351_ ARNKR 356_ ESGKA 361_ TSYAE 366_ LCSEY 371_ RKLVR 376_ NGKLA 381_ CTREN 386_ DPIQG 391_ PDGKV 396_ HGNTC 401_ SMCEV 406_ FFQAE 411_ EEEKK 416_ KKEGK 421_ SRNKR 426_ QSKST 431_ ASFEE 436_ LCSEY 441_ RKSRK 446_ NGRLF 451_ CTREN 456_ DPIQG 461_ PDGKM 466_ HGNTC 471_ SMCEA 476_ FFQQE 481_ ERARA 486_ KAKRE 491_ AAKEI 496_ CSEFR 501_ DQVRN 506_ GTLIC 511_ TREHN 516_ PVRGP 521_ DGKMH 526_ GNKCA 531_ MCASV 536_ FKLEE 541_ EEKKN 546_ DKEEK 551_ GKVEA 556_ EKVKR 561_ EAVQE 566_ LCSEY 571_ RHYVR 576_ NGRLP 581_ CTREN 586_ DPIEG 591_ LDGKI 596_ HGNTC 601_ SMCEA 606_ FFQQE 611_ AKEKE 616_ RAEPR 621_ AKVKR 626_ EAEKE 631_ TCDEF 636_ RRLLQ 641_ NGKLF 646_ CTREN 651_ DPVRG 656_ PDGKT 661_ HGNKC 666_ AMCKA 671_ VFQKE 676_ NEERK 681_ RKEEE 686_ DQRNA 691_ AGHGS 696_ SGGGG 701_ GNTQD 706_ ECAEY 711_ REQMK 716_ NGRLS 721_ CTRES 726_ DPVRD 731_ ADGKS 736_ YNNQC 741_ TMCKA 746_ KLERE 751_ AERKN 756_ EYSRS 761_ RSNGT 766_ GSESG 771_ KDTCD 776_ EFRSQ 781_ MKNGK 786_ LICTR 791_ ESDPV 796_ RGPDG 801_ KTHGN 806_ KCTMC 811_ KEKLE 816_ REAAE 821_ KKKKE 826_ DEDRS 831_ NTGER 836_ SNTGE 841_ RSNDK 846_ EDLCR 851_ EFRSM 856_ QRNGK 861_ LICTR 866_ ENNPV 871_ RGPYG 876_ KMHIN 881_ KCAMC 886_ QSIFD 891_ REANE 896_ RKKKD 901_ EEKSS 906_ SKPSN 911_ NAKDE 916_ CSEFR 921_ NYIRN 926_ NELIC 931_ PREND 936_ PVHGA 941_ DGKFY 946_ TNKCY 951_ MCRAV 956_ FLTEA 961_ LERAK 966_ LQEKP 971_ SHVRA 976_ SQEED 981_ SPDSF 986_ SSLDS 991_ EMCKD 996_ YRVLP 1001_ RIGYL 1006_ CPKDL 1011_ KPVCG 1016_ DDGQT 1021_ YNNPC 1026_ MLCHE 1031_ NLIRQ 1036_ TNTHI 1041_ RSTGK 1046_ CEESS 1051_ TPGTT 1056_AASMP
1: Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin