1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1)
1_MAGAQ 6_ PGVHA 11_ LQLKP 16_ VCVSD 21_ SLKKG 26_ TKFVK 31_ WDDDS 36_ TIVTP 41_ IILRT 46_ DPQGF 51_ FFYWT 56_ DQNKE 61_ TELLD 66_ LSLVK 71_ DARCG 76_ RHAKA 81_ PKDPK 86_ LRELL 91_ DVGNI 96_ GRLEQ 101_ RMITV 106_ VYGPD 111_ LVNIS 116_ HLNLV 121_ AFQEE 126_ VAKEW 131_ TNEVF 136_ SLATN 141_ LLAQN 146_ MSRDA 151_ FLEKA 156_ YTKLK 161_ LQVTP 166_ EGRIP 171_ LKNIY 176_ RLFSA 181_ DRKRV 186_ ETALE 191_ ACSLP 196_ SSRND 201_ SIPQE 206_ DFTPE 211_ VYRVF 216_ LNNLC 221_ PRPEI 226_ DNIFS 231_ EFGAK 236_ SKPYL 241_ TVDQM 246_ MDFIN 251_ LKQRD 256_ PRLNE 261_ ILYPP 266_ LKQEQ 271_ VQVLI 276_ EKYEP 281_ NNSLA 286_ RKGQI 291_ SVDGF 296_ MRYLS 301_ GEENG 306_ VVSPE 311_ KLDLN 316_ EDMSQ 321_ PLSHY 326_ FINSS 331_ HNTYL 336_ TAGQL 341_ AGNSS 346_ VEMYR 351_ QVLLS 356_ GCRCV 361_ ELDCW 366_ KGRTA 371_ EEEPV 376_ ITHGF 381_ TMTTE 386_ ISFKE 391_ VIEAI 396_ AECAF 401_ KTSPF 406_ PILLS 411_ FENHV 416_ DSPKQ 421_ QAKMA 426_ EYCRL 431_ IFGDA 436_ LLMEP 441_ LEKYP 446_ LESGV 451_ PLPSP 456_ MDLMY 461_ KILVK 466_ NKKKS 471_ HKSSE 476_ GSGKK 481_ KLSEQ 486_ ASNTY 491_ SDSSS 496_ MFEPS 501_ SPGAG 506_ EADTE 511_ SDDDD 516_ DDDDC 521_ KKSSM 526_ DEGTA 531_ GSEAM 536_ ATEEM 541_ SNLVN 546_ YIQPV 551_ KFESF 556_ EISKK 561_ RNKSF 566_ EMSSF 571_ VETKG 576_ LEQLT 581_ KSPVE 586_ FVEYN 591_ KMQLS 596_ RIYPK 601_ GTRVD 606_ SSNYM 611_ PQLFW 616_ NAGCQ 621_ MVALN 626_ FQTMD 631_ LAMQI 636_ NMGMY 641_ EYNGK 646_ SGYRL 651_ KPEFM 656_ RRPDK 661_ HFDPF 666_ TEGIV 671_ DGIVA 676_ NTLSV 681_ KIISG 686_ QFLSD 691_ KKVGT 696_ YVEVD 701_ MFGLP 706_ VDTRR 711_ KAFKT 716_ KTSQG 721_ NAVNP 726_ VWEEE 731_ PIVFK 736_ KVVLP 741_ TLACL 746_ RIAVY 751_ EEGGK 756_ FIGHR 761_ ILPVQ 766_ AIRPG 771_ YHYIC 776_ LRNER 781_ NQPLT 786_ LPAVF 791_ VYIEV 796_ KDYVP 801_ DTYAD 806_ VIEAL 811_ SNPIR 816_ YVNLM 821_ EQRAK 826_ QLAAL 831_ TLEDE 836_ EEVKK 841_ EADPG 846_ ETPSE 851_ APSEA 856_ RTTPA 861_ ENGVN 866_ HTTTL 871_ TPKPP 876_ SQALH 881_ SQPAP 886_ GSVKA 891_ PAKTE 896_ DLIQS 901_ VLTEV 906_ EAQTI 911_ EELKQ 916_ QKSFV 921_ KLQKK 926_ HYKEM 931_ KDLVK 936_ RHHKK 941_ TTDLI 946_ KEHTT 951_ KYNEI 956_ QNDYL 961_ RRRAA 966_ LEKSA 971_ KKDSK 976_ KKSEP 981_ SSPDH 986_ GSSTI 991_ EQDLA 996_ ALDAE 1001_ MTQKL 1006_ IDLKD 1011_ KQQQQ 1016_ LLNLR 1021_ QEQYY 1026_ SEKYQ 1031_ KREHI 1036_ KLLIQ 1041_ KLTDV 1046_ AEECQ 1051_ NNQLK 1056_ KLKEI 1061_ CEKEK 1066_ KELKK 1071_ KMDKK 1076_ RQEKI 1081_ TEAKS 1086_ KDKSQ 1091_ MEEEK 1096_ TEMIR 1101_ SYIQE 1106_ VVQYI 1111_ KRLEE 1116_ AQSKR 1121_ QEKLV 1126_ EKHKE 1131_ IRQQI 1136_ LDEKP 1141_ KLQVE 1146_ LEQEY 1151_ QDKFK 1156_ RLPLE 1161_ ILEFV 1166_ QEAMK 1171_ GKISE 1176_ DSNHG 1181_ SAPLS 1186_ LSSDP 1191_ GKVNH 1196_ KTPSS 1201_ EELGG 1206_ DIPGK 1211_EFDTP
1: Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed:9188725). Regulates the function of the endothelial barrier