Coordinator of PRMT5 and differentiation stimulator (Cooperator of PRMT5) (Protein TTP1)
1_MDLQA 6_ AGAQA 11_ QGAAE 16_ PSRGP 21_ PLPSA 26_ RGAPP 31_ SPEAG 36_ FATAD 41_ HSSQE 46_ RETEK 51_ AMDRL 56_ ARGTQ 61_ SIPND 66_ SPARG 71_ EGTHS 76_ EEEGF 81_ AMDEE 86_ DSDGE 91_ LNTWE 96_ LSEGT 101_ NCPPK 106_ EQPGD 111_ LFNED 116_ WDSEL 121_ KADQG 126_ NPYDA 131_ DDIQE 136_ SISQE 141_ LKPWV 146_ CCAPQ 151_ GDMIY 156_ DPSWH 161_ HPPPL 166_ IPYYS 171_ KMVFE 176_TGQFD
1: Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity)