Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)
1_MPQLN 6_ GGGGD 11_ DLGAN 16_ DELIS 21_ FKDEG 26_ EQEEK 31_ SSENS 36_ SAERD 41_ LADVK 46_ SSLVN 51_ ESETN 56_ QNSSS 61_ DSEAE 66_ RRPPP 71_ RSESF 76_ RDKSR 81_ ESLEE 86_ AAKRQ 91_ DGGLF 96_ KGPPY 101_ PGYPF 106_ IMIPD 111_ LTSPY 116_ LPNGS 121_ LSPTA 126_ RTLHF 131_ QSGST 136_ HYSAY 141_ KTIEH 146_ QIAVQ 151_ YLQMK 156_ WPLLD 161_ VQAGS 166_ LQSRQ 171_ ALKDA 176_ RSPSP 181_ AHIVS 186_ NKVPV 191_ VQHPH 196_ HVHPL 201_ TPLIT 206_ YSNEH 211_ FTPGN 216_ PPPHL 221_ PADVD 226_ PKTGI 231_ PRPPH 236_ PPDIS 241_ PYYPL 246_ SPGTV 251_ GQIPH 256_ PLGWL 261_ VPQQG 266_ QPVYP 271_ ITTGG 276_ FRHPY 281_ PTALT 286_ VNASM 291_ SRFPP 296_ HMVPP 301_ HHTLH 306_ TTGIP 311_ HPAIV 316_ TPTVK 321_ QESSQ 326_ SDVGS 331_ LHSSK 336_ HQDSK 341_ KEEEK 346_ KKPHI 351_ KKPLN 356_ AFMLY 361_ MKEMR 366_ AKVVA 371_ ECTLK 376_ ESAAI 381_ NQILG 386_ RRWHA 391_ LSREE 396_ QAKYY 401_ ELARK 406_ ERQLH 411_ MQLYP 416_ GWSAR 421_ DNYGK 426_ KKKRK 431_ RDKQP 436_ GETNE 441_ HSECF 446_ LNPCL 451_ SLPPI 456_ TDLSA 461_ PKKCR 466_ ARFGL 471_ DQQNN 476_ WCGPC 481_ RRKKK 486_ CVRYI 491_ QGEGS 496_ CLSPP 501_ SSDGS 506_ LLDSP 511_ PPSPN 516_ LLGSP 521_ PRDAK 526_ SQTEQ 531_ TQPLS 536_ LSLKP 541_ DPLAH 546_ LSMMP 551_ PPPAL 556_ LLAEA 561_ THKAS 566_ ALCPN 571_ GALDL 576_ PPAAL 581_ QPAAP 586_ SSSIA 591_ QPSTS 596_ SLHSH 601_ SSLAG 606_ TQPQP 611_LSLVT
1: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine