E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15)
1_MEEKR 6_ RKYSI 11_ SSDNS 16_ DTTDS 21_ HATST 26_ SASRC 31_ SKLPS 36_ STKSG 41_ WPRQN 46_ EKKPS 51_ EVFRT 56_ DLITA 61_ MKIPD 66_ SYQLS 71_ PDDYY 76_ ILADP 81_ WRQEW 86_ EKGVQ 91_ VPAGA 96_ EAIPE 101_ PVVRI 106_ LPPLE 111_ GPPAQ 116_ ASPSS 121_ TMLGE 126_ GSQPD 131_ WPGGS 136_ RYDLD 141_ EIDAY 146_ WLELI 151_ NSELK 156_ EMERP 161_ ELDEL 166_ TLERV 171_ LEELE 176_ TLCHQ 181_ NMARA 186_ IETQE 191_ GLGIE 196_ YDEDV 201_ VCDVC 206_ RSPEG 211_ EDGNE 216_ MVFCD 221_ KCNVC 226_ VHQAC 231_ YGILK 236_ VPTGS 241_ WLCRT 246_ CALGV 251_ QPKCL 256_ LCPKR 261_ GGALK 266_ PTRSG 271_ TKWVH 276_ VSCAL 281_ WIPEV 286_ SIGCP 291_ EKMEP 296_ ITKIS 301_ HIPAS 306_ RWALS 311_ CSLCK 316_ ECTGT 321_ CIQCS 326_ MPSCV 331_ TAFHV 336_ TCAFD 341_ HGLEM 346_ RTILA 351_ DNDEV 356_ KFKSF 361_ CQEHS 366_ DGGPR 371_ NEPTS 376_ EPTEP 381_ SQAGE 386_ DLEKV 391_ TLRKQ 396_ RLQQL 401_ EEDFY 406_ ELVEP 411_ AEVAE 416_ RLDLA 421_ EALVD 426_ FIYQY 431_ WKLKR 436_ KANAN 441_ QPLLT 446_ PKTDE 451_ VDNLA 456_ QQEQD 461_ VLYRR 466_ LKLFT 471_ HLRQD 476_ LERVR 481_ NLCYM 486_ VTRRE 491_ RTKHA 496_ ICKLQ 501_ EQIFH 506_ LQMKL 511_ IEQDL 516_ CRGLS 521_ TSFPI 526_ DGTFF 531_ NSWLA 536_ QSVQI 541_ TAENM 546_ AMSEW 551_ PLNNG 556_ HREDP 561_ APGLL 566_ SEELL 571_ QDEET 576_ LLSFM 581_ RDPSL 586_ RPGDP 591_ ARKAR 596_ GRTRL 601_ PAKKK 606_ PPPPP 611_ PQDGP 616_ GSRTT 621_ PDKAP 626_ KKTWG 631_ QDAGS 636_ GKGGQ 641_ GPPTR 646_ KPPRR 651_ TSSHL 656_ PSSPA 661_ AGDCP 666_ ILATP 671_ ESPPP 676_ LAPET 681_ PDEAA 686_ SVAAD 691_ SDVQV 696_ PGPAA 701_ SPKPL 706_ GRLRP 711_ PRESK 716_ VTRRL 721_ PGARP 726_ DAGMG 731_ PPSAV 736_ AERPK 741_ VSLHF 746_ DTETD 751_ GYFSD 756_ GEMSD 761_ SDVEA 766_ EDGGV 771_ QRGPR 776_ EAGAE 781_EVVRM
1: Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity)