Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)
1_MEDLD 6_ QSPLV 11_ SSSDS 16_ PPRPQ 21_ PAFKY 26_ QFVRE 31_ PEDEE 36_ EEEEE 41_ EEEDE 46_ DEDLE 51_ ELEVL 56_ ERKPA 61_ AGLSA 66_ APVPT 71_ APAAG 76_ APLMD 81_ FGNDF 86_ VPPAP 91_ RGPLP 96_ AAPPV 101_ APERQ 106_ PSWDP 111_ SPVSS 116_ TVPAP 121_ SPLSA 126_ AAVSP 131_ SKLPE 136_ DDEPP 141_ ARPPP 146_ PPPAS 151_ VSPQA 156_ EPVWT 161_ PPAPA 166_ PAAPP 171_ STPAA 176_ PKRRG 181_ SSGSV 186_ DETLF 191_ ALPAA 196_ SEPVI 201_ RSSAE 206_ NMDLK 211_ EQPGN 216_ TISAG 221_ QEDFP 226_ SVLLE 231_ TAASL 236_ PSLSP 241_ LSAAS 246_ FKEHE 251_ YLGNL 256_ STVLP 261_ TEGTL 266_ QENVS 271_ EASKE 276_ VSEKA 281_ KTLLI 286_ DRDLT 291_ EFSEL 296_ EYSEM 301_ GSSFS 306_ VSPKA 311_ ESAVI 316_ VANPR 321_ EEIIV 326_ KNKDE 331_ EEKLV 336_ SNNIL 341_ HNQQE 346_ LPTAL 351_ TKLVK 356_ EDEVV 361_ SSEKA 366_ KDSFN 371_ EKRVA 376_ VEAPM 381_ REEYA 386_ DFKPF 391_ ERVWE 396_ VKDSK 401_ EDSDM 406_ LAAGG 411_ KIESN 416_ LESKV 421_ DKKCF 426_ ADSLE 431_ QTNHE 436_ KDSES 441_ SNDDT 446_ SFPST 451_ PEGIK 456_ DRSGA 461_ YITCA 466_ PFNPA 471_ ATESI 476_ ATNIF 481_ PLLGD 486_ PTSEN 491_ KTDEK 496_ KIEEK 501_ KAQIV 506_ TEKNT 511_ STKTS 516_ NPFLV 521_ AAQDS 526_ ETDYV 531_ TTDNL 536_ TKVTE 541_ EVVAN 546_ MPEGL 551_ TPDLV 556_ QEACE 561_ SELNE 566_ VTGTK 571_ IAYET 576_ KMDLV 581_ QTSEV 586_ MQESL 591_ YPAAQ 596_ LCPSF 601_ EESEA 606_ TPSPV 611_ LPDIV 616_ MEAPL 621_ NSAVP 626_ SAGAS 631_ VIQPS 636_ SSPLE 641_ ASSVN 646_ YESIK 651_ HEPEN 656_ PPPYE 661_ EAMSV 666_ SLKKV 671_ SGIKE 676_ EIKEP 681_ ENINA 686_ ALQET 691_ EAPYI 696_ SIACD 701_ LIKET 706_ KLSAE 711_ PAPDF 716_ SDYSE 721_ MAKVE 726_ QPVPD 731_ HSELV 736_ EDSSP 741_ DSEPV 746_ DLFSD 751_ DSIPD 756_ VPQKQ 761_ DETVM 766_ LVKES 771_ LTETS 776_ FESMI 781_ EYENK 786_ EKLSA 791_ LPPEG 796_ GKPYL 801_ ESFKL 806_ SLDNT 811_ KDTLL 816_ PDEVS 821_ TLSKK 826_ EKIPL 831_ QMEEL 836_ STAVY 841_ SNDDL 846_ FISKE 851_ AQIRE 856_ TETFS 861_ DSSPI 866_ EIIDE 871_ FPTLI 876_ SSKTD 881_ SFSKL 886_ AREYT 891_ DLEVS 896_ HKSEI 901_ ANAPD 906_ GAGSL 911_ PCTEL 916_ PHDLS 921_ LKNIQ 926_ PKVEE 931_ KISFS 936_ DDFSK 941_ NGSAT 946_ SKVLL 951_ LPPDV 956_ SALAT 961_ QAEIE 966_ SIVKP 971_ KVLVK 976_ EAEKK 981_ LPSDT 986_ EKEDR 991_ SPSAI 996_ FSAEL 1001_ SKTSV 1006_ VDLLY 1011_ WRDIK 1016_ KTGVV 1021_ FGASL 1026_ FLLLS 1031_ LTVFS 1036_ IVSVT 1041_ AYIAL 1046_ ALLSV 1051_ TISFR 1056_ IYKGV 1061_ IQAIQ 1066_ KSDEG 1071_ HPFRA 1076_ YLESE 1081_ VAISE 1086_ ELVQK 1091_ YSNSA 1096_ LGHVN 1101_ CTIKE 1106_ LRRLF 1111_ LVDDL 1116_ VDSLK 1121_ FAVLM 1126_ WVFTY 1131_ VGALF 1136_ NGLTL 1141_ LILAL 1146_ ISLFS 1151_ VPVIY 1156_ ERHQA 1161_ QIDHY 1166_ LGLAN 1171_ KNVKD 1176_ AMAKI 1181_ QAKIP 1186_GLKRK
1: Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:24262037, PubMed:25612671, PubMed:27619977). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:24262037, PubMed:25612671, PubMed:27619977, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable)
2: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS (PubMed:10667797, PubMed:11201742). Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Acts as a negative regulator of central nervous system angiogenesis. Inhibits spreading, migration and sprouting of primary brain microvascular endothelial cells (MVECs). Also induces the retraction of MVECs lamellipodia and filopodia in a ROCK pathway-dependent manner (By similarity)
3: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remodeling, promotes the migration of endothelial cells but inhibits the migration of vascular smooth muscle cells. Regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Inhibits serine palmitoyltransferase, SPTLC1, the rate-limiting enzyme of the novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine-1-phosphate (S1P). Required to promote macrophage homing and functions such as cytokine/chemokine gene expression involved in angiogenesis, arteriogenesis and tissue repair. Mediates ICAM1 induced transendothelial migration of leukocytes such as monocytes and neutrophils and acute inflammation. Necessary for immune responses triggered by nucleic acid sensing TLRs, such as TLR9, is required for proper TLR9 location to endolysosomes. Also involved in immune response to LPS. Plays a role in liver regeneration through the modulation of hepatocytes proliferation (By similarity). Reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration (PubMed:11126360). With isoform C, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550)
4: Regulates cardiomyocyte apoptosis upon hypoxic conditions (By similarity). With isoform B, inhibits BACE1 activity and amyloid precursor protein processing (PubMed:16965550)