Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)
1_MSSGL 6_ WSQEK 11_ VTSPY 16_ WEERI 21_ FYLLL 26_ QECSV 31_ TDKQT 36_ QKLLK 41_ VPKGS 46_ IGQYI 51_ QDRSV 56_ GHSRI 61_ PSAKG 66_ KKNQI 71_ GLKIL 76_ EQPHA 81_ VLFVD 86_ EKDVV 91_ EINEK 96_ FTELL 101_ LAITN 106_ CEERF 111_ SLFKN 116_ RNRLS 121_ KGLQI 126_ DVGCP 131_ VKVQL 136_ RSGEE 141_ KFPGV 146_ VRFRG 151_ PLLAE 156_ RTVSG 161_ IFFGV 166_ ELLEE 171_ GRGQG 176_ FTDGV 181_ YQGKQ 186_ LFQCD 191_ EDCGV 196_ FVALD 201_ KLELI 206_ EDDDT 211_ ALESD 216_ YAGPG 221_ DTMQV 226_ ELPPL 231_ EINSR 236_ VSLKV 241_ GETIE 246_ SGTVI 251_ FCDVL 256_ PGKES 261_ LGYFV 266_ GVDMD 271_ NPIGN 276_ WDGRF 281_ DGVQL 286_ CSFAC 291_ VESTI 296_ LLHIN 301_ DIIPA 306_ LSESV 311_ TQERR 316_ PPKLA 321_ FMSRG 326_ VGDKG 331_ SSSHN 336_ KPKAT 341_ GSTSD 346_ PGNRN 351_ RSELF 356_ YTLNG 361_ SSVDS 366_ QPQSK 371_ SKNTW 376_ YIDEV 381_ AEDPA 386_ KSLTE 391_ ISTDF 396_ DRSSP 401_ PLQPP 406_ PVNSL 411_ TTENR 416_ FHSLP 421_ FSLTK 426_ MPNTN 431_ GSIGH 436_ SPLSL 441_ SAQSV 446_ MEELN 451_ TAPVQ 456_ ESPPL 461_ AMPPG 466_ NSHGL 471_ EVGSL 476_ AEVKE 481_ NPPFY 486_ GVIRW 491_ IGQPP 496_ GLNEV 501_ LAGLE 506_ LEDEC 511_ AGCTD 516_ GTFRG 521_ TRYFT 526_ CALKK 531_ ALFVK 536_ LKSCR 541_ PDSRF 546_ ASLQP 551_ VSNQI 556_ ERCNS 561_ LAFGG 566_ YLSEV 571_ VEENT 576_ PPKME 581_ KEGLE 586_ IMIGK 591_ KKGIQ 596_ GHYNS 601_ CYLDS 606_ TLFCL 611_ FAFSS 616_ VLDTV 621_ LLRPK 626_ EKNDV 631_ EYYSE 636_ TQELL 641_ RTEIV 646_ NPLRI 651_ YGYVC 656_ ATKIM 661_ KLRKI 666_ LEKVE 671_ AASGF 676_ TSEEK 681_ DPEEF 686_ LNILF 691_ HHILR 696_ VEPLL 701_ KIRSA 706_ GQKVQ 711_ DCYFY 716_ QIFME 721_ KNEKV 726_ GVPTI 731_ QQLLE 736_ WSFIN 741_ SNLKF 746_ AEAPS 751_ CLIIQ 756_ MPRFG 761_ KDFKL 766_ FKKIF 771_ PSLEL 776_ NITDL 781_ LEDTP 786_ RQCRI 791_ CGGLA 796_ MYECR 801_ ECYDD 806_ PDISA 811_ GKIKQ 816_ FCKTC 821_ NTQVH 826_ LHPKR 831_ LNHKY 836_ NPVSL 841_ PKDLP 846_ DWDWR 851_ HGCIP 856_ CQNME 861_ LFAVL 866_ CIETS 871_ HYVAF 876_ VKYGK 881_ DDSAW 886_ LFFDS 891_ MADRD 896_ GGQNG 901_ FNIPQ 906_ VTPCP 911_ EVGEY 916_ LKMSL 921_ EDLHS 926_ LDSRR 931_ IQGCA 936_ RRLLC 941_ DAYMC 946_ MYQSP 951_TMSLY
1: Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18313383, PubMed:18636086, PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049, PubMed:27746020, PubMed:29291351, PubMed:32185393). Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors (PubMed:12917689, PubMed:12917691, PubMed:32185393). Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690). Negative regulator of Wnt signaling (PubMed:20227366). Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890). Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491). Inhibits nuclear translocation of NF-kappa-B (PubMed:18636086). Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells (By similarity). Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity). Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-alpha-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins (PubMed:26670046, PubMed:26997266, PubMed:27458237, PubMed:27591049). Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (PubMed:26997266). Involved in TNF-alpha-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (PubMed:29291351). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (PubMed:34497368)