Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor)
1_MSSFS 6_ ESALE 11_ KKLSE 16_ LSNSQ 21_ QSVQT 26_ LSLWL 31_ IHHRK 36_ HAGPI 41_ VSVWH 46_ RELRK 51_ AKSNR 56_ KLTFL 61_ YLAND 66_ VIQNS 71_ KRKGP 76_ EFTRE 81_ FESVL 86_ VDAFS 91_ HVARE 96_ ADEGC 101_ KKPLE 106_ RLLNI 111_ WQERS 116_ VYGGE 121_ FIQQL 126_ KLSME 131_ DSKSP 136_ PPKAT 141_ EEKKS 146_ LKRTF 151_ QQIQE 156_ EEDDD 161_ YPGSY 166_ SPQDP 171_ SAGPL 176_ LTEEL 181_ IKALQ 186_ DLENA 191_ ASGDA 196_ TVRQK 201_ IASLP 206_ QEVQD 211_ VSLLE 216_ KITDK 221_ EAAER 226_ LSKTV 231_ DEACL 236_ LLAEY 241_ NGRLA 246_ AELED 251_ RRQLA 256_ RMLVE 261_ YTQNQ 266_ KDVLS 271_ EKEKK 276_ LEEYK 281_ QKLAR 286_ VTQVR 291_ KELKS 296_ HIQSL 301_ PDLSL 306_ LPNVT 311_ GGLAP 316_ LPSAG 321_DLFST
1: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation