Mitochondrial dynamics protein MID51 (Mitochondrial dynamics protein of 51 kDa) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like) (SMCR7-like protein)
1_MAGAG 6_ ERKGK 11_ KDDNG 16_ IGTAI 21_ DFVLS 26_ NARLV 31_ LGVGG 36_ AAMLG 41_ IATLA 46_ VKRMY 51_ DRAIS 56_ APTSP 61_ TRLSH 66_ SGKRS 71_ WEEPN 76_ WMGSP 81_ RLLNR 86_ DMKTG 91_ LSRSL 96_ QTLPT 101_ DSSTF 106_ DTDTF 111_ CPPRP 116_ KPVAR 121_ KGQVD 126_ LKKSR 131_ LRMSL 136_ QEKLL 141_ TYYRN 146_ RAAIP 151_ AGEQA 156_ RAKQA 161_ AVDIC 166_ AELRS 171_ FLRAK 176_ LPDMP 181_ LRDMY 186_ LSGSL 191_ YDDLQ 196_ VVTAD 201_ HIQLI 206_ VPLVL 211_ EQNLW 216_ SCIPG 221_ EDTIM 226_ NVPGF 231_ FLVRR 236_ ENPEY 241_ FPRGS 246_ SYWDR 251_ CVVGG 256_ YLSPK 261_ TVADT 266_ FEKVV 271_ AGSIN 276_ WPAIG 281_ SLLDY 286_ VIRPA 291_ PPPEA 296_ LTLEV 301_ QYERD 306_ KHLFI 311_ DFLPS 316_ VTLGD 321_ TVLVA 326_ KPHRL 331_ AQYDN 336_ LWRLS 341_ LRPAE 346_ TARLR 351_ ALDQA 356_ DSGCR 361_ SLCLK 366_ ILKAI 371_ CKSTP 376_ ALGHL 381_ TASQL 386_ TNVIL 391_ HLAQE 396_ EADWS 401_ PDMLA 406_ DRFLQ 411_ ALRGL 416_ ISYLE 421_ AGVLP 426_ SALNP 431_ KVNLF 436_ AELTP 441_ EEIDE 446_ LGYTL 451_ YCSLS 456_EPEVL
1: Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics (PubMed:21701560, PubMed:23921378, PubMed:33632269). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L