Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3)
1_MPWLL 6_ SAPKL 11_ VPAVA 16_ NVRGL 21_ SGCML 26_ CSQRR 31_ YSLQP 36_ VPERR 41_ IPNRY 46_ LGQPS 51_ PFTHP 56_ HLLRP 61_ GEVTP 66_ GLSQV 71_ EYALR 76_ RHKLM 81_ SLIQK 86_ EAQGQ 91_ SGTDQ 96_ TVVVL 101_ SNPTY 106_ YMSND 111_ IPYTF 116_ HQDNN 121_ FLYLC 126_ GFQEP 131_ DSILV 136_ LQSLP 141_ GKQLP 146_ SHKAI 151_ LFVPR 156_ RDPSR 161_ ELWDG 166_ PRSGT 171_ DGAIA 176_ LTGVD 181_ EAYTL 186_ EEFQH 191_ LLPKM 196_ KAETN 201_ MVWYD 206_ WMRPS 211_ HAQLH 216_ SDYMQ 221_ PLTEA 226_ KAKSK 231_ NKVRG 236_ VQQLI 241_ QRLRL 246_ IKSPA 251_ EIERM 256_ QIAGK 261_ LTSQA 266_ FIETM 271_ FTSKA 276_ PVEEA 281_ FLYAK 286_ FEFEC 291_ RARGA 296_ DILAY 301_ PPVVA 306_ GGNRS 311_ NTLHY 316_ VKNNQ 321_ LIKDG 326_ EMVLL 331_ DGGCE 336_ SSCYV 341_ SDITR 346_ TWPVN 351_ GRFTA 356_ PQAEL 361_ YEAVL 366_ EIQRD 371_ CLALC 376_ FPGTS 381_ LENIY 386_ SMMLT 391_ LIGQK 396_ LKDLG 401_ IMKNI 406_ KENNA 411_ FKAAR 416_ KYCPH 421_ HVGHY 426_ LGMDV 431_ HDTPD 436_ MPRSL 441_ PLQPG 446_ MVITI 451_ EPGIY 456_ IPEDD 461_ KDAPE 466_ KFRGL 471_ GVRIE 476_ DDVVV 481_ TQDSP 486_ LILSA 491_ DCPKE 496_ MNDIE 501_QICSQ
1: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala (PubMed:25609706, PubMed:28476889). Also shows low activity towards peptides with Ala or Ser at the P1 position (PubMed:28476889)
2: Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling