Probable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Vasa homolog)
1_MGDED 6_ WEAEI 11_ NPHMS 16_ SYVPI 21_ FEKDR 26_ YSGEN 31_ GDNFN 36_ RTPAS 41_ SSEMD 46_ DGPSR 51_ RDHFM 56_ KSGFA 61_ SGRNF 66_ GNRDA 71_ GECNK 76_ RDNTS 81_ TMGGF 86_ GVGKS 91_ FGNRG 96_ FSNSR 101_ FEDGD 106_ SSGFW 111_ RESSN 116_ DCEDN 121_ PTRNR 126_ GFSKR 131_ GGYRD 136_ GNNSE 141_ ASGPY 146_ RRGGR 151_ GSFRG 156_ CRGGF 161_ GLGSP 166_ NNDLD 171_ PDECM 176_ QRTGG 181_ LFGSR 186_ RPVLS 191_ GTGNG 196_ DTSQS 201_ RSGSG 206_ SERGG 211_ YKGLN 216_ EEVIT 221_ GSGKN 226_ SWKSE 231_ AEGGE 236_ SSDTQ 241_ GPKVT 246_ YIPPP 251_ PPEDE 256_ DSIFA 261_ HYQTG 266_ INFDK 271_ YDTIL 276_ VEVSG 281_ HDAPP 286_ AILTF 291_ EEANL 296_ CQTLN 301_ NNIAK 306_ AGYTK 311_ LTPVQ 316_ KYSIP 321_ IILAG 326_ RDLMA 331_ CAQTG 336_ SGKTA 341_ AFLLP 346_ ILAHM 351_ MHDGI 356_ TASRF 361_ KELQE 366_ PECII 371_ VAPTR 376_ ELVNQ 381_ IYLEA 386_ RKFSF 391_ GTCVR 396_ AVVIY 401_ GGTQL 406_ GHSIR 411_ QIVQG 416_ CNILC 421_ ATPGR 426_ LMDII 431_ GKEKI 436_ GLKQI 441_ KYLVL 446_ DEADR 451_ MLDMG 456_ FGPEM 461_ KKLIS 466_ CPGMP 471_ SKEQR 476_ QTLMF 481_ SATFP 486_ EEIQR 491_ LAAEF 496_ LKSNY 501_ LFVAV 506_ GQVGG 511_ ACRDV 516_ QQTVL 521_ QVGQF 526_ SKREK 531_ LVEIL 536_ RNIGD 541_ ERTMV 546_ FVETK 551_ KKADF 556_ IATFL 561_ CQEKI 566_ STTSI 571_ HGDRE 576_ QRERE 581_ QALGD 586_ FRFGK 591_ CPVLV 596_ ATSVA 601_ ARGLD 606_ IENVQ 611_ HVINF 616_ DLPST 621_ IDEYV 626_ HRIGR 631_ TGRCG 636_ NTGRA 641_ ISFFD 646_ LESDN 651_ HLAQP 656_ LVKVL 661_ TDAQQ 666_ DVPAW 671_ LEEIA 676_ FSTYI 681_ PGFSG 686_ STRGN 691_ VFASV 696_ DTRKG 701_ KSTLN 706_ TAGFS 711_ SSQAP 716_NPVDD
1: ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity). Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs (By similarity)