Ras-related GTP-binding protein D (Rag D) (RagD) (EC 3.6.5.-)
1_MSQVL 6_ GKPQP 11_ QDEDD 16_ AEEEE 21_ EEDEL 26_ VGLAD 31_ YGDGP 36_ DSSDA 41_ DPDSG 46_ TEEGV 51_ LDFSD 56_ PFSTE 61_ VKPRI 66_ LLMGL 71_ RRSGK 76_ SSIQK 81_ VVFHK 86_ MSPNE 91_ TLFLE 96_ STNKI 101_ CREDV 106_ SNSSF 111_ VNFQI 116_ WDFPG 121_ QIDFF 126_ DPTFD 131_ YEMIF 136_ RGTGA 141_ LIFVI 146_ DSQDD 151_ YMEAL 156_ ARLHL 161_ TVTRA 166_ YKVNT 171_ DINFE 176_ VFIHK 181_ VDGLS 186_ DDHKI 191_ ETQRD 196_ IHQRA 201_ NDDLA 206_ DAGLE 211_ KIHLS 216_ FYLTS 221_ IYDHS 226_ IFEAF 231_ SKVVQ 236_ KLIPQ 241_ LPTLE 246_ NLLNI 251_ FISNS 256_ GIEKA 261_ FLFDV 266_ VSKIY 271_ IATDS 276_ TPVDM 281_ QTYEL 286_ CCDMI 291_ DVVID 296_ ISCIY 301_ GLKED 306_ GAGTP 311_ YDKES 316_ TAIIK 321_ LNNTT 326_ VLYLK 331_ EVTKF 336_ LALVC 341_ FVREE 346_ SFERK 351_ GLIDY 356_ NFHCF 361_ RKAIH 366_ EVFEV 371_ RMKVV 376_ KSRKV 381_ QNRLQ 386_ KKKRA 391_TPNGT
1: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:24095279, PubMed:34607910). Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagD/RRAGD is in its active form when GDP-bound RagD/RRAGD forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagD/RRAGD heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB) (PubMed:24095279). In its active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:24095279). This is a crucial step in the activation of the MTOR signaling cascade by amino acids (PubMed:20381137, PubMed:24095279). Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagD/RRAGD mediates recruitment of MiT/TFE factors TFEB and TFE3 (PubMed:32612235)