Nectin-3 (CDw113) (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113)
1_MARTL 6_ RPSPL 11_ CPGGG 16_ KAQLS 21_ SASLL 26_ GAGLL 31_ LQPPT 36_ PPPLL 41_ LLLFP 46_ LLLFS 51_ RLCGA 56_ LAGPI 61_ IVEPH 66_ VTAVW 71_ GKNVS 76_ LKCLI 81_ EVNET 86_ ITQIS 91_ WEKIH 96_ GKSSQ 101_ TVAVH 106_ HPQYG 111_ FSVQG 116_ EYQGR 121_ VLFKN 126_ YSLND 131_ ATITL 136_ HNIGF 141_ SDSGK 146_ YICKA 151_ VTFPL 156_ GNAQS 161_ STTVT 166_ VLVEP 171_ TVSLI 176_ KGPDS 181_ LIDGG 186_ NETVA 191_ AICIA 196_ ATGKP 201_ VAHID 206_ WEGDL 211_ GEMES 216_ TTTSF 221_ PNETA 226_ TIISQ 231_ YKLFP 236_ TRFAR 241_ GRRIT 246_ CVVKH 251_ PALEK 256_ DIRYS 261_ FILDI 266_ QYAPE 271_ VSVTG 276_ YDGNW 281_ FVGRK 286_ GVNLK 291_ CNADA 296_ NPPPF 301_ KSVWS 306_ RLDGQ 311_ WPDGL 316_ LASDN 321_ TLHFV 326_ HPLTF 331_ NYSGV 336_ YICKV 341_ TNSLG 346_ QRSDQ 351_ KVIYI 356_ SDPPT 361_ TTTLQ 366_ PTIQW 371_ HPSTA 376_ DIEDL 381_ ATEPK 386_ KLPFP 391_ LSTLA 396_ TIKDD 401_ TIATI 406_ IASVV 411_ GGALF 416_ IVLVS 421_ VLAGI 426_ FCYRR 431_ RRTFR 436_ GDYFA 441_ KNYIP 446_ PSDMQ 451_ KESQI 456_ DVLQQ 461_ DELDS 466_ YPDSV 471_ KKENK 476_ NPVNN 481_ LIRKD 486_ YLEEP 491_ EKTQW 496_ NNVEN 501_ LNRFE 506_ RPMDY 511_ YEDLK 516_ MGMKF 521_ VSDEH 526_ YDENE 531_ DDLVS 536_ HVDGS 541_VISRR
1: Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions (PubMed:16216929). Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1 (PubMed:16216929). Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation (PubMed:16216929). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (By similarity). Also involved in the formation of cell-cell junctions, including adherens junctions and synapses (By similarity). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (By similarity). Plays a role in the morphology of the ciliary body (By similarity)