G-protein coupled receptor 84 (Inflammation-related G-protein coupled receptor EX33)
1_MWNSS 6_ DANFS 11_ CYHES 16_ VLGYR 21_ YVAVS 26_ WGVVV 31_ AVTGT 36_ VGNVL 41_ TLLAL 46_ AIQPK 51_ LRTRF 56_ NLLIA 61_ NLTLA 66_ DLLYC 71_ TLLQP 76_ FSVDT 81_ YLHLH 86_ WRTGA 91_ TFCRV 96_ FGLLL 101_ FASNS 106_ VSILT 111_ LCLIA 116_ LGRYL 121_ LIAHP 126_ KLFPQ 131_ VFSAK 136_ GIVLA 141_ LVSTW 146_ VVGVA 151_ SFAPL 156_ WPIYI 161_ LVPVV 166_ CTCSF 171_ DRIRG 176_ RPYTT 181_ ILMGI 186_ YFVLG 191_ LSSVG 196_ IFYCL 201_ IHRQV 206_ KRAAQ 211_ ALDQY 216_ KLRQA 221_ SIHSN 226_ HVART 231_ DEAMP 236_ GRFQE 241_ LDSRL 246_ ASGGP 251_ SEGIS 256_ SEPVS 261_ AATTQ 266_ TLEGD 271_ SSEVG 276_ DQINS 281_ KRAKQ 286_ MAEKS 291_ PPEAS 296_ AKAQP 301_ IKGAR 306_ RAPDS 311_ SSEFG 316_ KVTRM 321_ CFAVF 326_ LCFAL 331_ SYIPF 336_ LLLNI 341_ LDARV 346_ QAPRV 351_ VHMLA 356_ ANLTW 361_ LNGCI 366_ NPVLY 371_ AAMNR 376_ QFRQA 381_ YGSIL 386_ KRGPR 391_SFHRL
1: G protein-coupled receptor that responds endogenously to dietary fatty acids or nutrient, specifically medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists (PubMed:16966319). In immune cells, functions as a pro-inflammatory receptor via 6-OAU and promotes the expression of pro-inflammatory mediators such as TNFalpha, IL-6 and IL-12B as well as stimulating chemotactic responses through activation of signaling mediators AKT, ERK and NF-kappa-B (By similarity). In addition, triggers increased bacterial adhesion and phagocytosis in macrophages and regulates pro-inflammatory function via enhancing NLRP3 inflammasome activation (By similarity). Also plays an important role in inflammation by modulating neutrophil functions (By similarity). Mechanistically, promotes neutrophil chemotaxis, reactive oxygen species (ROS) production and degranulation via LYN-AKT/ERK pathway (By similarity). To regulate ROS, communicates with the two formyl peptide receptors FPR2 and FPR1 to control the NADPH oxidase activity in neutrophils (PubMed:33789297)