Inner centromere protein
1_MGTTA 6_ PGPIH 11_ LLELC 16_ DQKLM 21_ EFLCN 26_ MDNKD 31_ LVWLE 36_ EIQEE 41_ AERMF 46_ TREFS 51_ KEPEL 56_ MPKTP 61_ SQKNR 66_ RKKRR 71_ ISYVQ 76_ DENRD 81_ PIRRR 86_ LSRRK 91_ SRSSQ 96_ LSSRR 101_ LRSKD 106_ SVEKL 111_ ATVVG 116_ ENGSV 121_ LRRVT 126_ RAAAA 131_ AAAAT 136_ MALAA 141_ PSSPT 146_ PESPT 151_ MLTKK 156_ PEDNH 161_ TQCQL 166_ VPVVE 171_ IGISE 176_ RQNAE 181_ QHVTQ 186_ LMSTE 191_ PLPRT 196_ LSPTP 201_ ASATA 206_ PTSQG 211_ IPTSD 216_ EESTP 221_ KKSKA 226_ RILES 231_ ITVSS 236_ LMATP 241_ QDPKG 246_ QGVGT 251_ GRSAS 256_ KLRIA 261_ QVSPG 266_ PRDSP 271_ AFPDS 276_ PWRER 281_ VLAPI 286_ LPDNF 291_ STPTG 296_ SRTDS 301_ QSVRH 306_ SPIAP 311_ SSPSP 316_ QVLAQ 321_ KYSLV 326_ AKQES 331_ VVRRA 336_ SRRLA 341_ KKTAE 346_ EPAAS 351_ GRIIC 356_ HSYLE 361_ RLLNV 366_ EVPQK 371_ VGSEQ 376_ KEPPE 381_ EAEPV 386_ AAAEP 391_ EVPEN 396_ NGNNS 401_ WPHND 406_ TEIAN 411_ STPNP 416_ KPAAS 421_ SPETP 426_ SAGQQ 431_ EAKTD 436_ QADGP 441_ REPPQ 446_ SARRK 451_ RSYKQ 456_ AVSEL 461_ DEEQH 466_ LEDEE 471_ LQPPR 476_ SKTPS 481_ SPCPA 486_ SKVVR 491_ PLRTF 496_ LHTVQ 501_ RNQML 506_ MTPTS 511_ APRSV 516_ MKSFI 521_ KRNTP 526_ LRMDP 531_ KCSFV 536_ EKERQ 541_ RLENL 546_ RRKEE 551_ AEQLR 556_ RQKVE 561_ EDKRR 566_ RLEEV 571_ KLKRE 576_ ERLRK 581_ VLQAR 586_ ERVEQ 591_ MKEEK 596_ KKQIE 601_ QKFAQ 606_ IDEKT 611_ EKAKE 616_ ERLAE 621_ EKAKK 626_ KAAAK 631_ KMEEV 636_ EARRK 641_ QEEEA 646_ RRLRW 651_ LQQEE 656_ EERRH 661_ QELLQ 666_ KKKEE 671_ EQERL 676_ RKAAE 681_ AKRLA 686_ EQREQ 691_ ERREQ 696_ ERREQ 701_ ERREQ 706_ ERREQ 711_ ERREQ 716_ ERQLA 721_ EQERR 726_ REQER 731_ LQAER 736_ ELQER 741_ EKALR 746_ LQKEQ 751_ LQREL 756_ EEKKK 761_ KEEQQ 766_ RLAER 771_ QLQEE 776_ QEKKA 781_ KEAAG 786_ ASKAL 791_ NVTVD 796_ VQSPA 801_ CTSYQ 806_ MTPQG 811_ HRAPP 816_ KINPD 821_ NYGMD 826_ LNSDD 831_ STDDE 836_ AHPRK 841_ PIPTW 846_ ARGTP 851_ LSQAI 856_ IHQYY 861_ HPPNL 866_ LELFG 871_ TILPL 876_ DLEDI 881_ FKKSK 886_ PRYHK 891_ RTSSA 896_ VWNSP 901_ PLQGA 906_ RVPSS 911_LAYSL
1: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:12925766, PubMed:15316025, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428)