Exosome complex component RRP40 (Exosome component 3) (Ribosomal RNA-processing protein 40) (p10)
1_MAEPA 6_ SVAAE 11_ SLAGS 16_ RARAA 21_ RTVLG 26_ QVVLP 31_ GEELL 36_ LPEQE 41_ DAEGP 46_ GGAVE 51_ RPLSL 56_ NARAC 61_ SRVRV 66_ VCGPG 71_ LRRCG 76_ DRLLV 81_ TKCGR 86_ LRHKE 91_ PGSGS 96_ GGGVY 101_ WVDSQ 106_ QKRYV 111_ PVKGD 116_ HVIGI 121_ VTAKS 126_ GDIFK 131_ VDVGG 136_ SEPAS 141_ LSYLS 146_ FEGAT 151_ KRNRP 156_ NVQVG 161_ DLIYG 166_ QFVVA 171_ NKDME 176_ PEMVC 181_ IDSCG 186_ RANGM 191_ GVIGQ 196_ DGLLF 201_ KVTLG 206_ LIRKL 211_ LAPDC 216_ EIIQE 221_ VGKLY 226_ PLEIV 231_ FGMNG 236_ RIWVK 241_ AKTIQ 246_ QTLIL 251_ ANILE 256_ ACEHM 261_ TSDQR 266_KQIFS
1: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5