Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)
1_MFRKK 6_ KKKRP 11_ EISAP 16_ QNFQH 21_ RVHTS 26_ FDPKE 31_ GKFVG 36_ LPPQW 41_ QNILD 46_ TLRRP 51_ KPVVD 56_ PSRIT 61_ RVQLQ 66_ PMKTV 71_ VRGSA 76_ MPVDG 81_ YISGL 86_ LNDIQ 91_ KLSVI 96_ SSNTL 101_ RGRSP 106_ TSRRR 111_ AQSLG 116_ LLGDE 121_ HWATD 126_ PDMYL 131_ QSPQS 136_ ERTDP 141_ HGLYL 146_ SCNGG 151_ TPAGH 156_ KQMPW 161_ PEPQS 166_ PRVLP 171_ NGLAA 176_ KAQSL 181_ GPAEF 186_ QGASQ 191_ RCLQL 196_ GACLQ 201_ SSPPG 206_ ASPPT 211_ GTNRH 216_ GMKAA 221_ KHGSE 226_ EARPQ 231_ SCLVG 236_ SATGR 241_ PGGEG 246_ SPSPK 251_ TRESS 256_ LKRRL 261_ FRSMF 266_ LSTAA 271_ TAPPS 276_ SSKPG 281_ PPPQS 286_ KPNSS 291_ FRPPQ 296_ KDNPP 301_ SLVAK 306_ AQSLP 311_ SDQPV 316_ GTFSP 321_ LTTSD 326_ TSSPQ 331_ KSLRT 336_ APATG 341_ QLPGR 346_ SSPAG 351_ SPRTW 356_ HAQIS 361_ TSNLY 366_ LPQDP 371_ TVAKG 376_ ALAGE 381_ DTGVV 386_ THEQF 391_ KAALR 396_ MVVDQ 401_ GDPRL 406_ LLDSY 411_ VKIGE 416_ GSTGI 421_ VCLAR 426_ EKHSG 431_ RQVAV 436_ KMMDL 441_ RKQQR 446_ RELLF 451_ NEVVI 456_ MRDYQ 461_ HFNVV 466_ EMYKS 471_ YLVGE 476_ ELWVL 481_ MEFLQ 486_ GGALT 491_ DIVSQ 496_ VRLNE 501_ EQIAT 506_ VCEAV 511_ LQALA 516_ YLHAQ 521_ GVIHR 526_ DIKSD 531_ SILLT 536_ LDGRV 541_ KLSDF 546_ GFCAQ 551_ ISKDV 556_ PKRKS 561_ LVGTP 566_ YWMAP 571_ EVISR 576_ SLYAT 581_ EVDIW 586_ SLGIM 591_ VIEMV 596_ DGEPP 601_ YFSDS 606_ PVQAM 611_ KRLRD 616_ SPPPK 621_ LKNSH 626_ KVSPV 631_ LRDFL 636_ ERMLV 641_ RDPQE 646_ RATAQ 651_ ELLDH 656_ PFLLQ 661_ TGLPE 666_ CLVPL 671_ IQLYR 676_KQTST
1: Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD