Cyclic nucleotide-gated cation channel beta-3 (Cone photoreceptor cGMP-gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel beta-3) (CNG channel beta-3)
1_MFKSL 6_ TKVNK 11_ VKPIG 16_ ENNEN 21_ EQSSR 26_ RNEEG 31_ SHPSN 36_ QSQQT 41_ TAQEE 46_ NKGEE 51_ KSLKT 56_ KSTPV 61_ TSEEP 66_ HTNIQ 71_ DKLSK 76_ KNSSG 81_ DLTTN 86_ PDPQN 91_ AAEPT 96_ GTVPE 101_ QKEMD 106_ PGKEG 111_ PNSPQ 116_ NKPPA 121_ APVIN 126_ EYADA 131_ QLHNL 136_ VKRMR 141_ QRTAL 146_ YKKKL 151_ VEGDL 156_ SSPEA 161_ SPQTA 166_ KPTAV 171_ PPVKE 176_ SDDKP 181_ TEHYY 186_ RLLWF 191_ KVKKM 196_ PLTEY 201_ LKRIK 206_ LPNSI 211_ DSYTD 216_ RLYLL 221_ WLLLV 226_ TLAYN 231_ WNCCF 236_ IPLRL 241_ VFPYQ 246_ TADNI 251_ HYWLI 256_ ADIIC 261_ DIIYL 266_ YDMLF 271_ IQPRL 276_ QFVRG 281_ GDIIV 286_ DSNEL 291_ RKHYR 296_ TSTKF 301_ QLDVA 306_ SIIPF 311_ DICYL 316_ FFGFN 321_ PMFRA 326_ NRMLK 331_ YTSFF 336_ EFNHH 341_ LESIM 346_ DKAYI 351_ YRVIR 356_ TTGYL 361_ LFILH 366_ INACV 371_ YYWAS 376_ NYEGI 381_ GTTRW 386_ VYDGE 391_ GNEYL 396_ RCYYW 401_ AVRTL 406_ ITIGG 411_ LPEPQ 416_ TLFEI 421_ VFQLL 426_ NFFSG 431_ VFVFS 436_ SLIGQ 441_ MRDVI 446_ GAATA 451_ NQNYF 456_ RACMD 461_ DTIAY 466_ MNNYS 471_ IPKLV 476_ QKRVR 481_ TWYEY 486_ TWDSQ 491_ RMLDE 496_ SDLLK 501_ TLPTT 506_ VQLAL 511_ AIDVN 516_ FSIIS 521_ KVDLF 526_ KGCDT 531_ QMIYD 536_ MLLRL 541_ KSVLY 546_ LPGDF 551_ VCKKG 556_ EIGKE 561_ MYIIK 566_ HGEVQ 571_ VLGGP 576_ DGTKV 581_ LVTLK 586_ AGSVF 591_ GEISL 596_ LAAGG 601_ GNRRT 606_ ANVVA 611_ HGFAN 616_ LLTLD 621_ KKTLQ 626_ EILVH 631_ YPDSE 636_ RILMK 641_ KARVL 646_ LKQKA 651_ KTAEA 656_ TPPRK 661_ DLALL 666_ FPPKE 671_ ETPKL 676_ FKTLL 681_ GGTGK 686_ ASLAR 691_ LLKLK 696_ REQAA 701_ QKKEN 706_ SEGGE 711_ EEGKE 716_ NEDKQ 721_ KENED 726_ KQKEN 731_ EDKGK 736_ ENEDK 741_ DKGRE 746_ PEEKP 751_ LDRPE 756_ CTASP 761_ IAVEE 766_ EPHSV 771_ RRTVL 776_ PRGTS 781_ RQSLI 786_ ISMAP 791_ SAEGG 796_ EEVLT 801_IEVKE
1: Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations