Putative histone-lysine N-methyltransferase PRDM6 (EC 2.1.1.361) (PR domain zinc finger protein 6) (PR domain-containing protein 6)
1_MLKPG 6_ DPGGS 11_ AFLKV 16_ DPAYL 21_ QHWQQ 26_ LFPHG 31_ GAGPL 36_ KGSGA 41_ AGLLS 46_ APQPL 51_ QPPPP 56_ PPPPE 61_ RAEPP 66_ PDSLR 71_ PRPAS 76_ LSSAS 81_ STPAS 86_ SSTSA 91_ SSASS 96_ CAAAA 101_ AAAAL 106_ AGLSA 111_ LPVSQ 116_ LPVFA 121_ PLAAA 126_ AVAAE 131_ PLPPK 136_ ELCLG 141_ ATSGP 146_ GPVKC 151_ GGGGG 156_ GGGEG 161_ RGAPR 166_ FRCSA 171_ EELDY 176_ YLYGQ 181_ QRMEI 186_ IPLNQ 191_ HTSDP 196_ NNRCD 201_ MCADN 206_ RNGEC 211_ PMHGP 216_ LHSLR 221_ RLVGT 226_ SSAAA 231_ AAPPP 236_ ELPEW 241_ LRDLP 246_ REVCL 251_ CTSTV 256_ PGLAY 261_ GICAA 266_ QRIQQ 271_ GTWIG 276_ PFQGV 281_ LLPPE 286_ KVQAG 291_ AVRNT 296_ QHLWE 301_ IYDQD 306_ GTLQH 311_ FIDGG 316_ EPSKS 321_ SWMRY 326_ IRCAR 331_ HCGEQ 336_ NLTVV 341_ QYRSN 346_ IFYRA 351_ CIDIP 356_ RGTEL 361_ LVWYN 366_ DSYTS 371_ FFGIP 376_ LQCIA 381_ QDENL 386_ NVPST 391_ VMEAM 396_ CRQDA 401_ LQPFN 406_ KSSKL 411_ APTTQ 416_ QRSVV 421_ FPQTP 426_ CSRNF 431_ SLLDK 436_ SGPIE 441_ SGFNQ 446_ INVKN 451_ QRVLA 456_ SPTST 461_ SQLHS 466_ EFSDW 471_ HLWKC 476_ GQCFK 481_ TFTQR 486_ ILLQM 491_ HVCTQ 496_ NPDRP 501_ YQCGH 506_ CSQSF 511_ SQPSE 516_ LRNHV 521_ VTHSS 526_ DRPFK 531_ CGYCG 536_ RAFAG 541_ ATTLN 546_ NHIRT 551_ HTGEK 556_ PFKCE 561_ RCERS 566_ FTQAT 571_ QLSRH 576_ QRMPN 581_ ECKPI 586_TESPE
1: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression