Gephyrin [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)]
1_MATEG 6_ MILTN 11_ HDHQI 16_ RVGVL 21_ TVSDS 26_ CFRNL 31_ AEDRS 36_ GINLK 41_ DLVQD 46_ PSLLG 51_ GTISA 56_ YKIVP 61_ DEIEE 66_ IKETL 71_ IDWCD 76_ EKELN 81_ LILTT 86_ GGTGF 91_ APRDV 96_ TPEAT 101_ KEVIE 106_ REAPG 111_ MALAM 116_ LMGSL 121_ NVTPL 126_ GMLSR 131_ PVCGI 136_ RGKTL 141_ IINLP 146_ GSKKG 151_ SQECF 156_ QFILP 161_ ALPHA 166_ IDLLR 171_ DAIVK 176_ VKEVH 181_ DELED 186_ LPSPP 191_ PPLSP 196_ PPTTS 201_ PHKQT 206_ EDKGV 211_ QCEEE 216_ EEEKK 221_ DSGVA 226_ STEDS 231_ SSSHI 236_ TAAAI 241_ AAKIP 246_ DSIIS 251_ RGVQV 256_ LPRDT 261_ ASLST 266_ TPSES 271_ PRAQA 276_ TSRLS 281_ TASCP 286_ TPKVQ 291_ SRCSS 296_ KENIL 301_ RASHS 306_ AVDIT 311_ KVARR 316_ HRMSP 321_ FPLTS 326_ MDKAF 331_ ITVLE 336_ MTPVL 341_ GTEII 346_ NYRDG 351_ MGRVL 356_ AQDVY 361_ AKDNL 366_ PPFPA 371_ SVKDG 376_ YAVRA 381_ ADGPG 386_ DRFII 391_ GESQA 396_ GEQPT 401_ QTVMP 406_ GQVMR 411_ VTTGA 416_ PIPCG 421_ ADAVV 426_ QVEDT 431_ ELIRE 436_ SDDGT 441_ EELEV 446_ RILVQ 451_ ARPGQ 456_ DIRPI 461_ GHDIK 466_ RGECV 471_ LAKGT 476_ HMGPS 481_ EIGLL 486_ ATVGV 491_ TEVEV 496_ NKFPV 501_ VAVMS 506_ TGNEL 511_ LNPED 516_ DLLPG 521_ KIRDS 526_ NRSTL 531_ LATIQ 536_ EHGYP 541_ TINLG 546_ IVGDN 551_ PDDLL 556_ NALNE 561_ GISRA 566_ DVIIT 571_ SGGVS 576_ MGEKD 581_ YLKQV 586_ LDIDL 591_ HAQIH 596_ FGRVF 601_ MKPGL 606_ PTTFA 611_ TLDID 616_ GVRKI 621_ IFALP 626_ GNPVS 631_ AVVTC 636_ NLFVV 641_ PALRK 646_ MQGIL 651_ DPRPT 656_ IIKAR 661_ LSCDV 666_ KLDPR 671_ PEYHR 676_ CILTW 681_ HHQEP 686_ LPWAQ 691_ STGNQ 696_ MSSRL 701_ MSMRS 706_ ANGLL 711_ MLPPK 716_ TEQYV 721_ ELHKG 726_ EVVDV 731_MVIGR
1: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940)
2: Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released