Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3]
1_MVKIS 6_ FQPAV 11_ AGIKG 16_ DKADK 21_ ASASA 26_ PAPAS 31_ ATEIL 36_ LTPAR 41_ EEQPP 46_ QHRSK 51_ RGGSV 56_ GGVCY 61_ LSMGM 66_ VVLLM 71_ GLVFA 76_ SVYIY 81_ RYFFL 86_ AQLAR 91_ DNFFR 96_ CGVLY 101_ EDSLS 106_ SQVRT 111_ QMELE 116_ EDVKI 121_ YLDEN 126_ YERIN 131_ VPVPQ 136_ FGGGD 141_ PADII 146_ HDFQR 151_ GLTAY 156_ HDISL 161_ DKCYV 166_ IELNT 171_ TIVLP 176_ PRNFW 181_ ELLMN 186_ VKRGT 191_ YLPQT 196_ YIIQE 201_ EMVVT 206_ EHVSD 211_ KEALG 216_ SFIYH 221_ LCNGK 226_ DTYRL 231_ RRRAT 236_ RRRIN 241_ KRGAK 246_ NCNAI 251_ RHFEN 256_ TFVVE 261_TLICG
1: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity)