Something about silencing protein 10 (Charged amino acid-rich leucine zipper 1) (CRL1) (Disrupter of silencing SAS10) (UTP3 homolog)
1_MVGRS 6_ RRRGA 11_ AKWAA 16_ VRAKA 21_ GPTLT 26_ DENGD 31_ DLGLP 36_ PSPGD 41_ TSYYQ 46_ DQVDD 51_ FHEAR 56_ SRAAL 61_ AKGWN 66_ EVQSG 71_ DEEDG 76_ EEEEE 81_ EVLAL 86_ DMDDE 91_ DDEDG 96_ GNAGE 101_ EEEEE 106_ NADDD 111_ GGSSV 116_ QSEAE 121_ ASVDP 126_ SLSWG 131_ QRKKL 136_ YYDTD 141_ YGSKS 146_ RGRQS 151_ QQEAE 156_ EEERE 161_ EEEEA 166_ QIIQR 171_ RLAQA 176_ LQEDD 181_ FGVAW 186_ VEAFA 191_ KPVPQ 196_ VDEAE 201_ TRVVK 206_ DLAKV 211_ SVKEK 216_ LKMLR 221_ KESPE 226_ LLELI 231_ EDLKV 236_ KLTEV 241_ KDELE 246_ PLLEL 251_ VEQGI 256_ IPPGK 261_ GSQYL 266_ RTKYN 271_ LYLNY 276_ CSNIS 281_ FYLIL 286_ KARRV 291_ PAHGH 296_ PVIER 301_ LVTYR 306_ NLINK 311_ LSVVD 316_ QKLSS 321_ EIRHL 326_ LTLKD 331_ DAVKK 336_ ELIPK 341_ AKSTK 346_ PKPKS 351_ VSKTS 356_ AAACA 361_ VTDLS 366_ DDSDF 371_ DEKAK 376_ LKYYK 381_ EIEDR 386_ QKLKR 391_ KKEEN 396_ STEEQ 401_ ALEDQ 406_ NAKRA 411_ ITYQI 416_ AKNRG 421_ LTPRR 426_ KKIDR 431_ NPRVK 436_ HREKF 441_ RRAKI 446_ RRRGQ 451_ VREVR 456_ KEEQR 461_ YSGEL 466_ SGIRA 471_GVKKS
1: Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)