Baculoviral IAP repeat-containing protein 6 (EC 2.3.2.27) (BIR repeat-containing ubiquitin-conjugating enzyme) (BRUCE) (RING-type E3 ubiquitin transferase BIRC6) (Ubiquitin-conjugating BIR domain enzyme apollon) (APOLLON)
1_MVTGG 6_ GAAPP 11_ GTVTE 16_ PLPSV 21_ IVLSA 26_ GRKMA 31_ AAAAA 36_ ASGPG 41_ CSSAA 46_ GAGAA 51_ GVSEW 56_ LVLRD 61_ GCMHC 66_ DADGL 71_ HSLSY 76_ HPALN 81_ AILAV 86_ TSRGT 91_ IKVID 96_ GTSGA 101_ TLQAS 106_ ALSAK 111_ PGGQV 116_ KCQYI 121_ SAVDK 126_ VIFVD 131_ DYAVG 136_ CRKDL 141_ NGILL 146_ LDTAL 151_ QTPVS 156_ KQDDV 161_ VQLEL 166_ PVTEA 171_ QQLLS 176_ ACLEK 181_ VDISS 186_ TEGYD 191_ LFITQ 196_ LKDGL 201_ KNTSH 206_ ETAAN 211_ HKVAK 216_ WATVT 221_ FHLPH 226_ HVLKS 231_ IASAI 236_ VNELK 241_ KINQN 246_ VAALP 251_ VASSV 256_ MDRLS 261_ YLLPS 266_ ARPEL 271_ GVGPG 276_ RSVDR 281_ SLMYS 286_ EANRR 291_ ETFTS 296_ WPHVG 301_ YRWAQ 306_ PDPMA 311_ QAGFY 316_ HQPAS 321_ SGDDR 326_ AMCFT 331_ CSVCL 336_ VCWEP 341_ TDEPW 346_ SEHER 351_ HSPNC 356_ PFVKG 361_ EHTQN 366_ VPLSV 371_ TLATS 376_ PAQFP 381_ CTDGT 386_ DRISC 391_ FGSGS 396_ CPHFL 401_ AAATK 406_ RGKIC 411_ IWDVS 416_ KLMKV 421_ HLKFE 426_ INAYD 431_ PAIVQ 436_ QLILS 441_ GDPSS 446_ GVDSR 451_ RPTLA 456_ WLEDS 461_ SSCSD 466_ IPKLE 471_ GDSDD 476_ LLEDS 481_ DSEEH 486_ SRSDS 491_ VTGHT 496_ SQKEA 501_ MEVSL 506_ DITAL 511_ SILQQ 516_ PEKLQ 521_ WEIVA 526_ NVLED 531_ TVKDL 536_ EELGA 541_ NPCLT 546_ NSKSE 551_ KTKEK 556_ HQEQH 561_ NIPFP 566_ CLLAG 571_ GLLTY 576_ KSPAT 581_ SPISS 586_ NSHRS 591_ LDGLS 596_ RTQGE 601_ SISEQ 606_ GSTDN 611_ ESCTN 616_ SELNS 621_ PLVRR 626_ TLPVL 631_ LLYSI 636_ KESDE 641_ KAGKI 646_ FSQMN 651_ NIMSK 656_ SLHDD 661_ GFTVP 666_ QIIEM 671_ ELDSQ 676_ EQLLL 681_ QDPPV 686_ TYIQQ 691_ FADAA 696_ ANLTS 701_ PDSEK 706_ WNSVF 711_ PKPGT 716_ LVQCL 721_ RLPKF 726_ AEEEN 731_ LCIDS 736_ ITPCA 741_ DGIHL 746_ LVGLR 751_ TCPVE 756_ SLSAI 761_ NQVEA 766_ LNNLN 771_ KLNSA 776_ LCNRR 781_ KGELE 786_ SNLAV 791_ VNGAN 796_ ISVIQ 801_ HESPA 806_ DVQTP 811_ LIIQP 816_ EQRNV 821_ SGGYL 826_ VLYKM 831_ NYATR 836_ IVTLE 841_ EEPIK 846_ IQHIK 851_ DPQDT 856_ ITSLI 861_ LLPPD 866_ ILDNR 871_ EDDCE 876_ EPIED 881_ MQLTS 886_ KNGFE 891_ REKTS 896_ DISTL 901_ GHLVI 906_ TTQGG 911_ YVKIL 916_ DLSNF 921_ EILAK 926_ VEPPK 931_ KEGTE 936_ EQDTF 941_ VSVIY 946_ CSGTD 951_ RLCAC 956_ TKGGE 961_ LHFLQ 966_ IGGTC 971_ DDIDE 976_ ADILV 981_ DGSLS 986_ KGIEP 991_ SSEGS 996_ KPLSN 1001_ PSSPG 1006_ ISGVD 1011_ LLVDQ 1016_ PFTLE 1021_ ILTSL 1026_ VELTR 1031_ FETLT 1036_ PRFSA 1041_ TVPPC 1046_ WVEVQ 1051_ QEQQQ 1056_ RRHPQ 1061_ HLHQQ 1066_ HHGDA 1071_ AQHTR 1076_ TWKLQ 1081_ TDSNS 1086_ WDEHV 1091_ FELVL 1096_ PKACM 1101_ VGHVD 1106_ FKFVL 1111_ NSNIT 1116_ NIPQI 1121_ QVTLL 1126_ KNKAP 1131_ GLGKV 1136_ NALNI 1141_ EVEQN 1146_ GKPSL 1151_ VDLNE 1156_ EMQHM 1161_ DVEES 1166_ QCLRL 1171_ CPFLE 1176_ DHKED 1181_ ILCGP 1186_ VWLAS 1191_ GLDLS 1196_ GHAGM 1201_ LTLTS 1206_ PKLVK 1211_ GMAGG 1216_ KYRSF 1221_ LIHVK 1226_ AVNER 1231_ GTEEI 1236_ CNGGM 1241_ RPVVR 1246_ LPSLK 1251_ HQSNK 1256_ GYSLA 1261_ SLLAK 1266_ VAAGK 1271_ EKSSN 1276_ VKNEN 1281_ TSGTR 1286_ KSENL 1291_ RGCDL 1296_ LQEVS 1301_ VTIRR 1306_ FKKTS 1311_ ISKER 1316_ VQRCA 1321_ MLQFS 1326_ EFHEK 1331_ LLNTL 1336_ CRKTD 1341_ DGQIT 1346_ EHAQS 1351_ LVLDT 1356_ LCWLA 1361_ GVHSN 1366_ GPGSS 1371_ KEGNE 1376_ NLLSK 1381_ TRKFL 1386_ SDIVR 1391_ VCFFE 1396_ AGRSI 1401_ AHKCA 1406_ RFLAL 1411_ CISNG 1416_ KCDPC 1421_ QPAFG 1426_ PVLLK 1431_ ALLDN 1436_ MSFLP 1441_ AATTG 1446_ GSVYW 1451_ YFVLL 1456_ NYVKD 1461_ EDLAG 1466_ CSTAC 1471_ ASLLT 1476_ AVSRQ 1481_ LQDRL 1486_ TPMEA 1491_ LLQTR 1496_ YGLYS 1501_ SPFDP 1506_ VLFDL 1511_ EMSGS 1516_ SCKNV 1521_ YNSSI 1526_ GVQSD 1531_ EIDLS 1536_ DVLSG 1541_ NGKVS 1546_ SCTAA 1551_ EGSFT 1556_ SLTGL 1561_ LEVEP 1566_ LHFTC 1571_ VSTSD 1576_ GTRIE 1581_ RDDAM 1586_ SSFGV 1591_ TPAVG 1596_ GLSSG 1601_ TVGEA 1606_ STALS 1611_ SAAQV 1616_ ALQSL 1621_ SHAMA 1626_ SAEQQ 1631_ LQVLQ 1636_ EKQQQ 1641_ LLKLQ 1646_ QQKAK 1651_ LEAKL 1656_ HQTTA 1661_ AAAAA 1666_ ASAVG 1671_ PVHNS 1676_ VPSNP 1681_ VAAPG 1686_ FFIHP 1691_ SDVIP 1696_ PTPKT 1701_ TPLFM 1706_ TPPLT 1711_ PPNEA 1716_ VSVVI 1721_ NAELA 1726_ QLFPG 1731_ SVIDP 1736_ PAVNL 1741_ AAHNK 1746_ NSNKS 1751_ RMNPL 1756_ GSGLA 1761_ LAISH 1766_ ASHFL 1771_ QPPPH 1776_ QSIII 1781_ ERMHS 1786_ GARRF 1791_ VTLDF 1796_ GRPIL 1801_ LTDVL 1806_ IPTCG 1811_ DLASL 1816_ SIDIW 1821_ TLGEE 1826_ VDGRR 1831_ LVVAT 1836_ DISTH 1841_ SLILH 1846_ DLIPP 1851_ PVCRF 1856_ MKITV 1861_ IGRYG 1866_ STNAR 1871_ AKIPL 1876_ GFYYG 1881_ HTYIL 1886_ PWESE 1891_ LKLMH 1896_ DPLKG 1901_ EGESA 1906_ NQPEI 1911_ DQHLA 1916_ MMVAL 1921_ QEDIQ 1926_ CRYNL 1931_ ACHRL 1936_ ETLLQ 1941_ SIDLP 1946_ PLNSA 1951_ NNAQY 1956_ FLRKP 1961_ DKAVE 1966_ EDSRV 1971_ FSAYQ 1976_ DCIQL 1981_ QLQLN 1986_ LAHNA 1991_ VQRLK 1996_ VALGA 2001_ SRKML 2006_ SETSN 2011_ PEDLI 2016_ QTSST 2021_ EQLRT 2026_ IIRYL 2031_ LDTLL 2036_ SLLHA 2041_ SNGHS 2046_ VPAVL 2051_ QSTFH 2056_ AQACE 2061_ ELFKH 2066_ LCISG 2071_ TPKIR 2076_ LHTGL 2081_ LLVQL 2086_ CGGER 2091_ WWGQF 2096_ LSNVL 2101_ QELYN 2106_ SEQLL 2111_ IFPQD 2116_ RVFML 2121_ LSCIG 2126_ QRSLS 2131_ NSGVL 2136_ ESLLN 2141_ LLDNL 2146_ LSPLQ 2151_ PQLPM 2156_ HRRTE 2161_ GVLDI 2166_ PMISW 2171_ VVMLV 2176_ SRLLD 2181_ YVATV 2186_ EDEAA 2191_ AAKKP 2196_ LNGNQ 2201_ WSFIN 2206_ NNLHT 2211_ QSLNR 2216_ SSKGS 2221_ SSLDR 2226_ LYSRK 2231_ IRKQL 2236_ VHHKQ 2241_ QLNLL 2246_ KAKQK 2251_ ALVEQ 2256_ MEKEK 2261_ IQSNK 2266_ GSSYK 2271_ LLVEQ 2276_ AKLKQ 2281_ ATSKH 2286_ FKDLI 2291_ RLRRT 2296_ AEWSR 2301_ SNLDT 2306_ EVTTA 2311_ KESPE 2316_ IEPLP 2321_ FTLAH 2326_ ERCIS 2331_ VVQKL 2336_ VLFLL 2341_ SMDFT 2346_ CHADL 2351_ LLFVC 2356_ KVLAR 2361_ IANAT 2366_ RPTIH 2371_ LCEIV 2376_ NEPQL 2381_ ERLLL 2386_ LLVGT 2391_ DFNRG 2396_ DISWG 2401_ GAWAQ 2406_ YSLTC 2411_ MLQDI 2416_ LAGEL 2421_ LAPVA 2426_ AEAME 2431_ EGTVG 2436_ DDVGA 2441_ TAGDS 2446_ DDSLQ 2451_ QSSVQ 2456_ LLETI 2461_ DEPLT 2466_ HDITG 2471_ APPLS 2476_ SLEKD 2481_ KEIDL 2486_ ELLQD 2491_ LMEVD 2496_ IDPLD 2501_ IDLEK 2506_ DPLAA 2511_ KVFKP 2516_ ISSTW 2521_ YDYWG 2526_ ADYGT 2531_ YNYNP 2536_ YIGGL 2541_ GIPVA 2546_ KPPAN 2551_ TEKNG 2556_ SQTVS 2561_ VSVSQ 2566_ ALDAR 2571_ LEVGL 2576_ EQQAE 2581_ LMLKM 2586_ MSTLE 2591_ ADSIL 2596_ QALTN 2601_ TSPTL 2606_ SQSPT 2611_ GTDDS 2616_ LLGGL 2621_ QAANQ 2626_ TSQLI 2631_ IQLSS 2636_ VPMLN 2641_ VCFNK 2646_ LFSML 2651_ QVHHV 2656_ QLESL 2661_ LQLWL 2666_ TLSLN 2671_ SSSTG 2676_ NKENG 2681_ ADIFL 2686_ YNANR 2691_ IPVIS 2696_ LNQAS 2701_ ITSFL 2706_ TVLAW 2711_ YPNTL 2716_ LRTWC 2721_ LVLHS 2726_ LTLMT 2731_ NMQLN 2736_ SGSSS 2741_ AIGTQ 2746_ ESTAH 2751_ LLVSD 2756_ PNLIH 2761_ VLVKF 2766_ LSGTS 2771_ PHGTN 2776_ QHSPQ 2781_ VGPTA 2786_ TQAMQ 2791_ EFLTR 2796_ LQVHL 2801_ SSTCP 2806_ QIFSE 2811_ FLLKL 2816_ IHILS 2821_ TERGA 2826_ FQTGQ 2831_ GPLDA 2836_ QVKLL 2841_ EFTLE 2846_ QNFEV 2851_ VSVST 2856_ ISAVI 2861_ ESVTF 2866_ LVHHY 2871_ ITCSD 2876_ KVMSR 2881_ SGSDS 2886_ SVGAR 2891_ ACFGG 2896_ LFANL 2901_ IRPGD 2906_ AKAVC 2911_ GEMTR 2916_ DQLMF 2921_ DLLKL 2926_ VNILV 2931_ QLPLS 2936_ GNREY 2941_ SARVS 2946_ VTTNT 2951_ TDSVS 2956_ DEEKV 2961_ SGGKD 2966_ GNGSS 2971_ TSVQG 2976_ SPAYV 2981_ ADLVL 2986_ ANQQI 2991_ MSQIL 2996_ SALGL 3001_ CNSSA 3006_ MAMII 3011_ GASGL 3016_ HLTKH 3021_ ENFHG 3026_ GLDAI 3031_ SVGDG 3036_ LFTIL 3041_ TTLSK 3046_ KASTV 3051_ HMMLQ 3056_ PILTY 3061_ MACGY 3066_ MGRQG 3071_ SLATC 3076_ QLSEP 3081_ LLWFI 3086_ LRVLD 3091_ TSDAL 3096_ KAFHD 3101_ MGGVQ 3106_ LICNN 3111_ MVTST 3116_ RAIVN 3121_ TARSM 3126_ VSTIM 3131_ KFLDS 3136_ GPNKA 3141_ VDSTL 3146_ KTRIL 3151_ ASEPD 3156_ NAEGI 3161_ HNFAP 3166_ LGTIT 3171_ SSSPT 3176_ AQPAE 3181_ VLLQA 3186_ TPPHR 3191_ RARSA 3196_ AWSYI 3201_ FLPEE 3206_ AWCDL 3211_ TIHLP 3216_ AAVLL 3221_ KEIHI 3226_ QPHLA 3231_ SLATC 3236_ PSSVS 3241_ VEVSA 3246_ DGVNM 3251_ LPLST 3256_ PVVTS 3261_ GLTYI 3266_ KIQLV 3271_ KAEVA 3276_ SAVCL 3281_ RLHRP 3286_ RDAST 3291_ LGLSQ 3296_ IKLLG 3301_ LTAFG 3306_ TTSSA 3311_ TVNNP 3316_ FLPSE 3321_ DQVSK 3326_ TSIGW 3331_ LRLLH 3336_ HCLTH 3341_ ISDLE 3346_ GMMAS 3351_ AAAPT 3356_ ANLLQ 3361_ TCAAL 3366_ LMSPY 3371_ CGMHS 3376_ PNIEV 3381_ VLVKI 3386_ GLQST 3391_ RIGLK 3396_ LIDIL 3401_ LRNCA 3406_ ASGSD 3411_ PTDLN 3416_ SPLLF 3421_ GRLNG 3426_ LSSDS 3431_ TIDIL 3436_ YQLGT 3441_ TQDPG 3446_ TKDRI 3451_ QALLK 3456_ WVSDS 3461_ ARVAA 3466_ MKRSG 3471_ RMNYM 3476_ CPNSS 3481_ TVEYG 3486_ LLMPS 3491_ PSHLH 3496_ CVAAI 3501_ LWHSY 3506_ ELLVE 3511_ YDLPA 3516_ LLDQE 3521_ LFELL 3526_ FNWSM 3531_ SLPCN 3536_ MVLKK 3541_ AVDSL 3546_ LCSMC 3551_ HVHPN 3556_ YFSLL 3561_ MGWMG 3566_ ITPPP 3571_ VQCHH 3576_ RLSMT 3581_ DDSKK 3586_ QDLSS 3591_ SLTDD 3596_ SKNAQ 3601_ APLAL 3606_ TESHL 3611_ ATLAS 3616_ SSQSP 3621_ EAIKQ 3626_ LLDSG 3631_ LPSLL 3636_ VRSLA 3641_ SFCFS 3646_ HISSS 3651_ ESIAQ 3656_ SIDIS 3661_ QDKLR 3666_ RHHVP 3671_ QQCNK 3676_ MPITA 3681_ DLVAP 3686_ ILRFL 3691_ TEVGN 3696_ SHIMK 3701_ DWLGG 3706_ SEVNP 3711_ LWTAL 3716_ LFLLC 3721_ HSGST 3726_ SGSHN 3731_ LGAQQ 3736_ TSARS 3741_ ASLSS 3746_ AATTG 3751_ LTTQQ 3756_ RTAIE 3761_ NATVA 3766_ FFLQC 3771_ ISCHP 3776_ NNQKL 3781_ MAQVL 3786_ CELFQ 3791_ TSPQR 3796_ GNLPT 3801_ SGNIS 3806_ GFIRR 3811_ LFLQL 3816_ MLEDE 3821_ KVTMF 3826_ LQSPC 3831_ PLYKG 3836_ RINAT 3841_ SHVIQ 3846_ HPMYG 3851_ AGHKF 3856_ RTLHL 3861_ PVSTT 3866_ LSDVL 3871_ DRVSD 3876_ TPSIT 3881_ AKLIS 3886_ EQKDD 3891_ KEKKN 3896_ HEEKE 3901_ KVKAE 3906_ NGFQD 3911_ NYSVV 3916_ VASGL 3921_ KSQSK 3926_ RAVSA 3931_ TPPRP 3936_ PSRRG 3941_ RTIPD 3946_ KIGST 3951_ SGAEA 3956_ ANKII 3961_ TVPVF 3966_ HLFHK 3971_ LLAGQ 3976_ PLPAE 3981_ MTLAQ 3986_ LLTLL 3991_ YDRKL 3996_ PQGYR 4001_ SIDLT 4006_ VKLGS 4011_ RVITD 4016_ PSLSK 4021_ TDSYK 4026_ RLHPE 4031_ KDHGD 4036_ LLASC 4041_ PEDEA 4046_ LTPGD 4051_ ECMDG 4056_ ILDES 4061_ LLETC 4066_ PIQSP 4071_ LQVFA 4076_ GMGGL 4081_ ALIAE 4086_ RLPML 4091_ YPEVI 4096_ QQVSA 4101_ PVVTS 4106_ TTQEK 4111_ PKDSD 4116_ QFEWV 4121_ TIEQS 4126_ GELVY 4131_ EAPET 4136_ VAAEP 4141_ PPIKS 4146_ AVQTM 4151_ SPIPA 4156_ HSLAA 4161_ FGLFL 4166_ RLPGY 4171_ AEVLL 4176_ KERKH 4181_ AQCLL 4186_ RLVLG 4191_ VTDDG 4196_ EGSHI 4201_ LQSPS 4206_ ANVLP 4211_ TLPFH 4216_ VLRSL 4221_ FSTTP 4226_ LTTDD 4231_ GVLLR 4236_ RMALE 4241_ IGALH 4246_ LILVC 4251_ LSALS 4256_ HHSPR 4261_ VPNSS 4266_ VNQTE 4271_ PQVSS 4276_ SHNPT 4281_ STEEQ 4286_ QLYWA 4291_ KGTGF 4296_ GTGST 4301_ ASGWD 4306_ VEQAL 4311_ TKQRL 4316_ EEEHV 4321_ TCLLQ 4326_ VLASY 4331_ INPVS 4336_ SAVNG 4341_ EAQSS 4346_ HETRG 4351_ QNSNA 4356_ LPSVL 4361_ LELLS 4366_ QSCLI 4371_ PAMSS 4376_ YLRND 4381_ SVLDM 4386_ ARHVP 4391_ LYRAL 4396_ LELLR 4401_ AIASC 4406_ AAMVP 4411_ LLLPL 4416_ STENG 4421_ EEEEE 4426_ QSECQ 4431_ TSVGT 4436_ LLAKM 4441_ KTCVD 4446_ TYTNR 4451_ LRSKR 4456_ ENVKT 4461_ GVKPD 4466_ ASDQE 4471_ PEGLT 4476_ LLVPD 4481_ IQKTA 4486_ EIVYA 4491_ ATTSL 4496_ RQANQ 4501_ EKKLG 4506_ EYSKK 4511_ AAMKP 4516_ KPLSV 4521_ LKSLE 4526_ EKYVA 4531_ VMKKL 4536_ QFDTF 4541_ EMVSE 4546_ DEDGK 4551_ LGFKV 4556_ NYHYM 4561_ SQVKN 4566_ ANDAN 4571_ SAARA 4576_ RRLAQ 4581_ EAVTL 4586_ STSLP 4591_ LSSSS 4596_ SVFVR 4601_ CDEER 4606_ LDIMK 4611_ VLITG 4616_ PADTP 4621_ YANGC 4626_ FEFDV 4631_ YFPQD 4636_ YPSSP 4641_ PLVNL 4646_ ETTGG 4651_ HSVRF 4656_ NPNLY 4661_ NDGKV 4666_ CLSIL 4671_ NTWHG 4676_ RPEEK 4681_ WNPQT 4686_ SSFLQ 4691_ VLVSV 4696_ QSLIL 4701_ VAEPY 4706_ FNEPG 4711_ YERSR 4716_ GTPSG 4721_ TQSSR 4726_ EYDGN 4731_ IRQAT 4736_ VKWAM 4741_ LEQIR 4746_ NPSPC 4751_ FKEVI 4756_ HKHFY 4761_ LKRVE 4766_ IMAQC 4771_ EEWIA 4776_ DIQQY 4781_ SSDKR 4786_ VGRTM 4791_ SHHAA 4796_ ALKRH 4801_ TAQLR 4806_ EELLK 4811_ LPCPE 4816_ GLDPD 4821_ TDDAP 4826_ EVCRA 4831_ TTGAE 4836_ ETLMH 4841_ DQVKP 4846_ SSSKE 4851_LPSDF
1: Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase (PubMed:14765125, PubMed:15200957, PubMed:18329369). Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6 (PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). Ubiquitinates pro-apoptotic factors DIABLO/SMAC and HTRA2 (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106). DIABLO/SMAC antagonizes the caspase inhibition activity of BIRC6 by competing for the same binding sites as the caspases (PubMed:18329369, PubMed:36758106). Ubiquitinates the autophagy protein MAP1LC3B; this activity is also inhibited by DIABLO/SMAC (PubMed:36758105). Important regulator for the final stages of cytokinesis (PubMed:18329369). Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification (PubMed:18329369)