Protein mono-ADP-ribosyltransferase PARP11 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 11) (ARTD11) (Poly [ADP-ribose] polymerase 11) (PARP-11)
1_MWEAN 6_ PEMFH 11_ KAEEL 16_ FSKTT 21_ NNEVD 26_ DMDTS 31_ DTQWG 36_ WFYLA 41_ ECGKW 46_ HMFQP 51_ DTNSQ 56_ CSVSS 61_ EDIEK 66_ SFKTN 71_ PCGSI 76_ SFTTS 81_ KFSYK 86_ IDFAE 91_ MKQMN 96_ LTTGK 101_ QRLIK 106_ RAPFS 111_ ISAFS 116_ YICEN 121_ EAIPM 126_ PPHWE 131_ NVNTQ 136_ VPYQL 141_ IPLHN 146_ QTHEY 151_ NEVAN 156_ LFGKT 161_ MDRNR 166_ IKRIQ 171_ RIQNL 176_ DLWEF 181_ FCRKK 186_ AQLKK 191_ KRGVP 196_ QINEQ 201_ MLFHG 206_ TSSEF 211_ VEAIC 216_ IHNFD 221_ WRING 226_ IHGAV 231_ FGKGT 236_ YFARD 241_ AAYSS 246_ RFCKD 251_ DIKHG 256_ NTFQI 261_ HGVSL 266_ QQRHL 271_ FRTYK 276_ SMFLA 281_ RVLIG 286_ DYING 291_ DSKYM 296_ RPPSK 301_ DGSYV 306_ NLYDS 311_ CVDDT 316_ WNPKI 321_ FVVFD 326_ ANQIY 331_PEYLI
1: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:25673562). Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). Inhibits the type I interferon activated signaling pathway (PubMed:30988430). Mechanistically, mono-ADP-ribosylates beta-TrCP/BTRC to promote IFNAR1 ubiquitination and protect BTRC from ubiquitin-proteasome degradation. Additionally, acts as an antiviral factor by cooperating with PARP12 to suppress Zika virus replication, independent of IFNAR1 regulation or intrinsic PARP enzymatic activity (PubMed:34187568). Instead, facilitates the degradation of viral NS1 and NS3 proteins, potentially disrupting viral replication (PubMed:34187568)