Protein arginine N-methyltransferase 8 (EC 2.1.1.319) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4)
1_MGMKH 6_ SSRCL 11_ LLRRK 16_ MAENA 21_ AESTE 26_ VNSPP 31_ SQPPQ 36_ PVVPA 41_ KPVQC 46_ VHHVS 51_ TQPSC 56_ PGRGK 61_ MSKLL 66_ NPEEM 71_ TSRDY 76_ YFDSY 81_ AHFGI 86_ HEEML 91_ KDEVR 96_ TLTYR 101_ NSMYH 106_ NKHVF 111_ KDKVV 116_ LDVGS 121_ GTGIL 126_ SMFAA 131_ KAGAK 136_ KVFGI 141_ ECSSI 146_ SDYSE 151_ KIIKA 156_ NHLDN 161_ IITIF 166_ KGKVE 171_ EVELP 176_ VEKVD 181_ IIISE 186_ WMGYC 191_ LFYES 196_ MLNTV 201_ IFARD 206_ KWLKP 211_ GGLMF 216_ PDRAA 221_ LYVVA 226_ IEDRQ 231_ YKDFK 236_ IHWWE 241_ NVYGF 246_ DMTCI 251_ RDVAM 256_ KEPLV 261_ DIVDP 266_ KQVVT 271_ NACLI 276_ KEVDI 281_ YTVKT 286_ EELSF 291_ TSAFC 296_ LQIQR 301_ NDYVH 306_ ALVTY 311_ FNIEF 316_ TKCHK 321_ KMGFS 326_ TAPDA 331_ PYTHW 336_ KQTVF 341_ YLEDY 346_ LTVRR 351_ GEEIY 356_ GTISM 361_ KPNAK 366_ NVRDL 371_ DFTVD 376_ LDFKG 381_ QLCET 386_SVSND
1: S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer (PubMed:16051612, PubMed:17925405, PubMed:26529540, PubMed:26876602). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS (PubMed:18320585)