Growth/differentiation factor 3 (GDF-3)
1_MLRFL 6_ PDLAF 11_ SFLLI 16_ LALGQ 21_ AVQFQ 26_ EYVFL 31_ QFLGL 36_ DKAPS 41_ PQKFQ 46_ PVPYI 51_ LKKIF 56_ QDREA 61_ AATTG 66_ VSRDL 71_ CYVKE 76_ LGVRG 81_ NVLRF 86_ LPDQG 91_ FFLYP 96_ KKISQ 101_ ASSCL 106_ QKLLY 111_ FNLSA 116_ IKERE 121_ QLTLA 126_ QLGLD 131_ LGPNS 136_ YYNLG 141_ PELEL 146_ ALFLV 151_ QEPHV 156_ WGQTT 161_ PKPGK 166_ MFVLR 171_ SVPWP 176_ QGAVH 181_ FNLLD 186_ VAKDW 191_ NDNPR 196_ KNFGL 201_ FLEIL 206_ VKEDR 211_ DSGVN 216_ FQPED 221_ TCARL 226_ RCSLH 231_ ASLLV 236_ VTLNP 241_ DQCHP 246_ SRKRR 251_ AAIPV 256_ PKLSC 261_ KNLCH 266_ RHQLF 271_ INFRD 276_ LGWHK 281_ WIIAP 286_ KGFMA 291_ NYCHG 296_ ECPFS 301_ LTISL 306_ NSSNY 311_ AFMQA 316_ LMHAV 321_ DPEIP 326_ QAVCI 331_ PTKLS 336_ PISML 341_ YQDNN 346_ DNVIL 351_ RHYED 356_MVVDE
1: Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor CRIPTO (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and CRIPTO/Cripto (PubMed:21805089)