Diablo IAP-binding mitochondrial protein (Diablo homolog, mitochondrial) (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac)
1_MAALK 6_ SWLSR 11_ SVTSF 16_ FRYRQ 21_ CLCVP 26_ VVANF 31_ KKRCF 36_ SELIR 41_ PWHKT 46_ VTIGF 51_ GVTLC 56_ AVPIA 61_ QKSEP 66_ HSLSS 71_ EALMR 76_ RAVSL 81_ VTDST 86_ STFLS 91_ QTTYA 96_ LIEAI 101_ TEYTK 106_ AVYTL 111_ TSLYR 116_ QYTSL 121_ LGKMN 126_ SEEED 131_ EVWQV 136_ IIGAR 141_ AEMTS 146_ KHQEY 151_ LKLET 156_ TWMTA 161_ VGLSE 166_ MAAEA 171_ AYQTG 176_ ADQAS 181_ ITARN 186_ HIQLV 191_ KLQVE 196_ EVHQL 201_ SRKAE 206_ TKLAE 211_ AQIEE 216_ LRQKT 221_ QEEGE 226_ ERAES 231_EQEAY
1: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/BRUCE by inhibiting its binding to caspases (PubMed:15200957, PubMed:36758104, PubMed:36758105, PubMed:36758106)
2: Attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation
3: Defective in the capacity to down-regulate the XIAP/BIRC4 abundance